In vivo analysis of dendritic cell development and homeostasis

By Kang Liu, Gabriel D. Victora, T. Schwickert, P. Guermonprez, M. Meredith, Kai-Hui Yao, F. Chu, G. Randolph, Alexander Y. Rudensky, Michel C. Nussenzweig. Science, 2009

1,027 citations recorded by the source corpus.

Dendritic cells (DCs) in lymphoid tissue arise from precursors that also produce monocytes and plasmacytoid DCs (pDCs). Where DC and monocyte lineage commitment occurs and the nature of the DC precursor that migrates from the bone marrow to peripheral lymphoid organs are unknown. We show that DC development progresses from the macrophage and DC precursor to common DC precursors that give rise to pDCs and classical spleen DCs (cDCs), but not monocytes, and finally to committed precursors of cDCs (pre-cDCs). Pre-cDCs enter lymph nodes through and migrate along high endothelial venules and later disperse and integrate into the DC network. Further cDC development involves cell division, which is controlled in part by regulatory T cells and fms-like tyrosine kinase receptor-3.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/dd5a7cc87a0f010d1aeb73043dfd2db7eed37036

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In Immunology

Citations in the corpus

Macrophages: development and tissue specialization. (2015, result): “As opposed to earlier precursors, such as MDPs (65), these cMoPs have lost the potential to give rise to plasmacytoid DCs and classical DCs. Early studies established the existence of monocyte subsets in human blood (66).”
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Intestinal lamina propria dendritic cell subsets have different origin and functions. (2009, background): “Transfers of the immediate blood circulating precursors established that CD103+ CX3CR1 lpDCs arouse from recently reported DC-committed precursors (pre-cDCs) (Liu et al., 2009), whereas CD14+ CX3CR1 + lpDCs were derived from Ly6Chi but not Ly6Clo monocytes.”
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From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation (2014, background): “However, many DC and macrophage subpopulations [for example, lymphoid organ DC, plasmacytoid DC, skin Langerhans cells (LC), and brain microglia] originate from the MDP independent of monocytes (11, 18), and in some cases, they can even develop directly from the bone marrow (19).”
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Microbial stimulation fully differentiates monocytes to DC-SIGN/CD209+ dendritic cells for immune T cell areas (2010, background): “In the bone marrow, a common monocyte-DC precursor (Fogg et al., 2006) gives rise to monocytes and other precursors termed common DC precursors (Naik et al., 2007; Onai et al., 2007) and pre-cDCs (Liu et al., 2009).”
A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells (2012, methodology): “1 -/mice (4), B6 Flt3-Cre mice (5), B6 Mx1-Cre mice (6), FVB Tg(Csf1r Mer-iCre-Mer ) 1Jwp mice (7), and B6 Gt(ROSA)26Sor tm1(EYFP)Cos /J (Rosa26 LSL-YFP ) (8) have been previously described.”
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