Intestinal lamina propria dendritic cell subsets have different origin and functions.

By C. Varol, A. Vallon-Eberhard, Eran Elinav, T. Aychek, Y. Shapira, H. Luche, H. Fehling, W. Hardt, G. Shakhar, Steffen Jung. Immunity, 2009

786 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/23cb1d825b4a412c76eab0c50da9a83ae2b89dd9

How researchers see this paper

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In Immunology

1. Steffen Jung
2. A. Mildner
3. M. Guilliams
4. P. Murray
5. H. Hammad
6. B. Lambrecht
7. C. Varol
8. TA Wynn

Citations in the corpus

• Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment (2014, background): “opposed to the other tissue-resident macrophages analyzed, are mostly monocyte derived (Bain et al., 2014; Bogunovic et al., 2009; Varol et al., 2009).”
• The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages (2019, background): “Thus, circulating monocytes enter the gut and undergo final differentiation in the lamina propria to become mature, highly phagocytic macrophages capable of bactericidal activity via mechanisms such as NADPH-oxidase-derived reactive oxygen species (ROS) and antimicrobial peptides and proteins (Bain ”
• Intestinal homeostasis and its breakdown in inflammatory bowel disease (2011, background): “CD11c high CD103 + dendritic cells share developmental origins with lymphoid tissue dendritic cells and are derived from pre-dendritic cells without a monocyte intermediat”
• Progressive loss of RORγt expression confers distinct functional fates to natural killer cell receptor-expressing RORγt+ innate lymphocytes (2010, positive): “TNF was produced by myeloid cells phenotypically resembling macrophages or monocytederived cells (Figure S6D; Bogunovic et al., 2009; Varol et al., 2009).”
• Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF (2013, positive): “However, we and others have shown that intestinal MFs derive directly from BM-derived monocytes that continuously seed the lamina propria and differentiate locally into MFs (Bogunovic et al., 2009; Varol et al., 2009; Tamoutounour et al., 2012).”
• Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria. (2011, background): “Because these cells are gut resident (Schulz et al., 2009) and differ from classical DCs with respect to their developmental origin (Bogunovic et al., 2009; Varol et al., 2009), in the following we will refer to CX3CR1+CD11b+ LP cells as intestinal macrophages.”
• Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions (2009, background): “Similarly, Varol et al. (2009) demonstrated that Flt3L expanded CD103+CD11b DCs, the majority of which likely derive from intestinal isolated lymphoid tissues.”
• Protective and pathogenic functions of macrophage subsets (2011, background): “For example, colonic macrophages spend their existence bathed in IL-10 and mute any inflammatory response to the gut flora and their product”
• Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages (2012, background): “5 D), previously shown to be derived from CDPs (Bogunovic et al., 2009; Varol et al., 2009).”
• Ly6C hi monocytes in the inflamed colon give rise to proinflammatory effector cells and migratory antigen-presenting cells. (2012, methodology): “Data from adoptive monocyte transfers into macrophage-depleted animals have established that these cells are derived from Ly6C blood monocytes (Bogunovic et al., 2009; Varol et al., 2009).”
• Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8α+ conventional dendritic cells (2010, background): “Several intestinal DC subsets have been described in mice (Kelsall, 2008; Bogunovic et al., 2009; Varol et al., 2009).”