A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

By Christian Schulz, Elisa Gomez Perdiguero, Laurent Chorro, H. Szabo-Rogers, N. Cagnard, Katrin Kierdorf, Marco Prinz, Bishan Wu, S. Jacobsen, J. Pollard and 3 more. Science, 2012

2,497 citations recorded by the source corpus.

Subfields: Cell Biology, Immunology, Neurology

View Paper: https://www.semanticscholar.org/paper/6b0343c2b5b8c5f3e6eb720364f5b784133a701e

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Citations in the corpus

The biphasic function of microglia in ischemic stroke (2017, neutral): “In addition, microglia are a genetically distinct cell type in the mononuclear phagocyte system (Ginhoux et al., 2010; Schulz et al., 2012).”
Self-renewing resident cardiac macrophages limit adverse remodeling following myocardial infarction (2018, neutral): “Macrophages are specialized mononuclear phagocytes that reside in all tissues from the earliest stages of development, with particularly important roles in the response to injury 3, 4, 5, 6 .”
Metabolic Pathways In Immune Cell Activation And Quiescence (2013, background): “These cells are embryonically derived, seeded into tissues in utero, andmaintained by in situ proliferation (Geissmann et al., 2010; Schulz et al., 2012).”
Identification of a Unique TGF-β Dependent Molecular and Functional Signature in Microglia (2013, neutral): “We then investigated the expression of F4/80 at 90 days in CNS-TGF β 1 −/− mice; F4/80 stains organ specific macrophages and microglia 5,34 .”
The spleen in local and systemic regulation of immunity (2013, background): “In line with this notion, splenectomy before or early after tumor implantation can retard tumor growth in colon carcinoma, mammary carcinoma, and melanomabearing mice (Fotiadis et al., 1999; Schwarz and Hiserodt, 1990).”
Origin and Functions of Tissue Macrophages (2014, background): “Macrophage proliferation in adipose tissue has been reported to be dependent on MCP-1, as is monocyte emigration from bone marrow and entry into circulation and peripheral tissue (Serbina and Pamer, 2006; Amano et al., 2014).”
Neuroinflammation and M2 microglia: the good, the bad, and the inflamed (2014, background): “Furthermore, microglia are not macrophages that migrate into the brain, but instead are known to represent a distinct population of resident tissue mesenchymal cells that populate the CNS during early development [56,57].”
Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment (2014, background): “…demonstrated that most tissues are populated early during fetal development by macrophages that subsequently maintain themselves, independently of adult hematopoiesis, through longevity and limited self-renewal (Ginhoux et al., 2010; Hashimoto et al., 2013; Schulz et al., 2012; Yona et al., 2013).”