The lamellipodium: where motility begins.

By J. Small, T. Stradal, E. Vignal, K. Rottner. Trends in Cell Biology, 2002

961 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/dbe5eba610eca3d16eed5d9c0d73482bbb6116ca

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Citations in the corpus

Quantum dot ligands provide new insights into erbB/HER receptor–mediated signal transduction (2004, background): “We surmise that this novel form of retrograde transport involves complexes of EGF-QD-erbB1 with treadmilling actin filaments and/or actin-localized motor protein”
A bottom-up approach to cell mechanics (2006, background): “Fascinating demonstrations of functionally relevant heterogeneities are provided by the formation of filopodia (finger-like extensions of the cytoplasm sent out by the cell in motion), in which the local activation of different actin-binding proteins enables the dynamic generation of highly localize”
Cell adhesion: integrating cytoskeletal dynamics and cellular tension (2010, background): “Cells initiate the migration cycle by polarizing and extending protrusions of the cell membrane towards the cu”
Conserved microtubule–actin interactions in cell movement and morphogenesis (2003, background): “Similarly, Rac1 activity regulates the polymerization of both actin and microtubules to promote lamellipodial protrusio”
Molecular and Structural Basis for Redox Regulation of β-Actin (2007, background): “The constant and rapid reorganization of the actin microfilament system during cell motility and migration, mitogenesis, and phagocytosis depends on nucleation, elongation, and depolymerization of actin filaments as elementary processes.(6,7) The dynamic reorganization of cellular actin is highly re”
The Vascular Endothelium and Human Diseases (2013, background): “Lamellipodia are cytoplasmic protrusions that form at the leading edge of spreading or migrating cells (117).”
Rho GTPases in cell biology (2002, background): “Rac induces actin polymerization and integrin adhesion complex assembly at the cell periphery, leading to membrane protrusion, and it is essential for the migration of all cells examined so fa”
Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase (2005, background): “The molecular mechanisms that lead to focal adhesion assembly have been well characterized, with particular emphasis on the role of Rho family GTPases and integrin engagemen”
Environmental sensing through focal adhesions (2009, background): “— thin, flat, cellular extensions that are generated by actin-related protein 2/3 (Arp2/3) complex-mediated actin polymerizatio”
Mechanism of filopodia initiation by reorganization of a dendritic network (2003, background): “A frequent event in filopodial behavior is their fusion, which frequently occurs as elongating oblique bundles collide and subsequently grow as a single unit (Katoh et al., 1999b; Small et al., 2002).”