Quantum dot ligands provide new insights into erbB/HER receptor–mediated signal transduction

By D. Lidke, P. Nagy, Rainer Heintzmann, D. Arndt-Jovin, J. Post, H. Grecco, E. Jares-Erijman, T. Jovin. Nature Biotechnology, 2004

795 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/3f22032878658bfc757336ab48cfe90a0890a1a2

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In Molecular Biology

1. Igor L. Medintz
2. H. Mattoussi
3. Wolfgang J. Parak
4. Nicolas Bertaux
5. Reisa A. Sperling
6. P. Ray
7. Didier Marguet
8. Arnauld Sergé

In Oncology

1. Nicolas Bertaux
2. Didier Marguet
3. Arnauld Sergé
4. Hervé Rigneault

In Radiology, Nuclear Medicine and Imaging

1. Nicolas Bertaux
2. Reisa A. Sperling
3. Didier Marguet
4. Arnauld Sergé
5. Hervé Rigneault

Citations in the corpus

• Quantum dot bioconjugates for imaging, labelling and sensing (2005, background): “Additionally, the specific erbB/HER cellular receptor-mediated fusion and internalization process has been observed in single cell”
• Effects of nanomaterial physicochemical properties on in vivo toxicity (2009, background): “, labeling neoplastic cells, peroxisomes, DNA, and cell membrane receptors) after conjugation with specific bioactive moieties [80-85].”
• Dynamic multiple-target tracing to probe spatiotemporal cartography of cell membranes (2008, background): “has considerably increased the sensitivity of detection and greatly facilitated biological investigations of cellular processe”
• Skeletal muscle stem cells express anti-apoptotic ErbB receptors during activation from quiescence. (2007, positive): “ErbB1 is the common receptor bound by EGF and HB-EGF, although subsequent signal transduction can occur either via erbB1 homodimers or via erbB1/erbB2 heterodimers [50,51].”
• Interactions of nanomaterials and biological systems: implications to personalized nanomedicine (2012, neutral): “used quantum dots (QDs) conjugated to epidermal growth factor (EGF) to study erbB/HER receptormediated cellular response to EGF in living human epidermoid carcinoma A431 cells, assigning the mechanism of EGF-induced signaling to heterodimerization of erbB1 and erbB2 monomers and uncovering retrograd”
• Surface modification, functionalization and bioconjugation of colloidal inorganic nanoparticles (2010, background): “Streptavidin-functionalized nanoparticles have been used to label the biotinylated motor protein kinesin with quantum dots (Courty et al. 2006), or biotinylated epidermal growth factor (Lidke et al. 2004).”
• Toxicity and Environmental Risks of Nanomaterials: Challenges and Future Needs (2009, positive): “One of the more valuable properties of QDs is their fluorescence spectrum, which renders them as optimal fluorophores for biomedical imaging; eg, fluorescent QDs can be conjugated with bioactive moieties to target specific biologic events and cellular structures such as labeling neoplastic cells, DN”