Rho GTPases in cell biology

By Sandrine Étienne-Manneville, A. Hall. Nature, 2002

4,907 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/e625c8787d34a5113ee817f52d0debfb95fcb1ca

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. A. Ridley
2. C. Der
3. A. Hall
4. S. Heasman
5. Yi Zhong
6. Krister Wennerberg
7. J. Condeelis
8. K. Rossman

In Molecular Biology

1. A. Ridley
2. David M. Sabatini
3. C. Der
4. Michael N. Hall
5. S. Heasman
6. K. Rossman
7. A. Hall
8. Yi Zhong

Citations in the corpus

• Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis. (2006, background): “We also analyzed the active guanosine triphosphate (GTP) bound form of the small GTPase RhoA (Etienne-Manneville and Hall, 2002) since inhibition of Rho-Rho kinase signaling stimulates differentiation of mouse calvarial osteoblasts (Harmey et al., 2004).”
• Cardiovascular actions of insulin. (2007, background): “In addition, insulin stimulates phosphorylation of RhoA at Ser188, which prevents it from binding to and activating ROK- (66).”
• Pathways of clathrin-independent endocytosis (2007, background): “However, this terminology is not meant to imply that a given GTPase is directly involved only in a particular internalization mechanism — these pathways have been primarily defined by mutants of these GTPases, which are likely to affect many cellular processe”
• Cell migration: Rho GTPases lead the way. (2004, background): “Most notably, Cdc42 is required for the establishment of cell polarity, while all three can, in distinct ways, affect the microtubule cytoskeleton and gene transcription (Etienne-Manneville and Hall, 2002).”
• Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive (2004, background): “In mammals, Rho, Rac and Cdc42 are among the well characterized members of the Rho family of GTPases that regulate F-actin assembly and disassembl”
• Signalling to and from tight junctions (2003, background): “Given the importance of Rho-family GTPases in the regulation of the actin cytoskeleto”
• The emerging role of lysophosphatidic acid in cancer (2003, background): “Finally, LPA activates G 12/13 , leading to activation of the small GTPase RHOA, which drives cytoskeletal contraction and cell roundin”
• CDK inhibitors: cell cycle regulators and beyond. (2008, positive): “Rho and its effector Rho-kinase (ROCK) are best known for their role in the regulation of actinstress-fiber formation, focal-adhesion assembly, as well as actin-myosin contractility (Etienne-Manneville and Hall, 2002).”
• Conserved microtubule–actin interactions in cell movement and morphogenesis (2003, background): “For example, RhoA mediates formation of contractile actin structures, such as stress fibre”
• Diffuse glioma growth: a guerilla war (2007, background): “These latter proteins are activators of the Actin-related protein Arp2/3 complex, a nucleator of new actin Wlaments at the leading edge of the cell and thereby instrumental for protrusion of lamellipodia and Wlopodia [47, 124, 142].”
• Targeting mitochondrial glutaminase activity inhibits oncogenic transformation (2010, positive): “Rho-family GTPases activate signaling pathways that influence a variety of cellular activities ranging from actin cytoskeletal rearrangements to cell polarity and migration, cell cycle pro- gression, and membrane trafficking (Etienne-Manneville and Hall 2002).”
• Rho-Kinase/ROCK: A Key Regulator of the Cytoskeleton and Cell Polarity (2010, background): “Rho family GTPases play critical roles in regulation of cell migration through their specific effectors [Etienne-Manneville and Hall, 2002; Fukata et al., 2003].”