The Vascular Endothelium and Human Diseases

By Peramaiyan Rajendran, T. Rengarajan, Jayakumar Thangavel, Y. Nishigaki, D. Sakthisekaran, Gautam Sethi, I. Nishigaki. International Journal on Biological Sciences, 2013

1,375 citations recorded by the source corpus.

Alterations of endothelial cells and the vasculature play a central role in the pathogenesis of a broad spectrum of the most dreadful of human diseases, as endothelial cells have the key function of participating in the maintenance of patent and functional capillaries. The endothelium is directly involved in peripheral vascular disease, stroke, heart disease, diabetes, insulin resistance, chronic kidney failure, tumor growth, metastasis, venous thrombosis, and severe viral infectious diseases. Dysfunction of the vascular endothelium is thus a hallmark of human diseases. In this review the main endothelial abnormalities found in various human diseases such as cancer, diabetes mellitus, atherosclerosis, and viral infections are addressed.

Subfields: Food Science, Plant Science

View Paper: https://www.semanticscholar.org/paper/228702f187c35969633400ece2572978d949185a

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Citations in the corpus

• Endothelial Dysfunction and Hypertension. (2016, background): “As a result, endothelial dysfunction is related to several diseases including atherosclerosis, cancer metastasis, inflammatory diseases and hypertension (Rajendran et al. 2013).”
• Endothelial Dysfunction in Atherosclerotic Cardiovascular Diseases and Beyond: From Mechanism to Pharmacotherapies (2021, background): “Endothelium is unique as a distributed organ because it is directly exposed to pressure and flow, with uniform and disturbed patterns that change in association with the cardiac cycle (Ramanathan and Skinner, 2005).”