CD4+CD25+ regulatory T cells down‐regulate co‐stimulatory molecules on antigen‐presenting cells

By Lukas Cederbom, H. Hall, F. Ivars. European Journal of Immunology, 2000

625 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/dbb955265a673aebd32b4731e3a178818ca1abea

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In Immunology

Citations in the corpus

Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice (2007, background): “In tissue culture studies, T reg cells have been shown to inhibit the maturation and to alter the cytokine production of DC”
How regulatory T cells work (2008, background): “Ivars and colleagues first reported that T Reg cells could downregulate the expression of the co-stimulatory molecules CD80 and CD86 by DCs in vitro”
Human Cd25+Cd4+ T Regulatory Cells Suppress Naive and Memory T Cell Proliferation and Can Be Expanded in Vitro without Loss of Function (2001, background): “CD25 CD4 T cells were stimulated with allogeneic APCs and increasing numbers of autologous CD25 CD4 Tr cells were added.”
Regulatory T cells in the control of immune pathology (2001, background): “Coculture with activated CD4 + CD25 + T cells led to reduced amounts of the costimulatory molecules CD80 and CD86 on DCs and B cell”
CD4+CD25+ suppressor T cells: more questions than answers (2002, neutral): “These observations should be compared with those of Cederbom et al”
Modulation of tryptophan catabolism by regulatory T cells (2003, background): “, others have raised the possibility that they act by suppressing APC functio”
Cd4+Cd25+ Immune Regulatory Cells Are Required for Induction of Tolerance to Alloantigen via Costimulatory Blockade (2001, neutral): “Although other studies have indicated that cell– cell contact appears to be required for the downregulatory capacity of CD4 CD25 cells, it is possible that unidentified, labile, soluble factor(s) may be involved (15, 19, 20, 24).”
CD8+ T Cell Immunity Against a Tumor/Self-Antigen Is Augmented by CD4+ T Helper Cells and Hindered by Naturally Occurring T Regulatory Cells (2005, background): “Alternatively, Treg cells may condition the APC toward tolerance (47).”
The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses (2011, background): “Interestingly, T Reg cells can reduce the expression levels of the co-stimulatory ligands CD80 and CD86 on APC”