CD4+CD25+ suppressor T cells: more questions than answers

By E. Shevach. Nature reviews. Immunology, 2002

2,432 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Suppression of allergic airway inflammation by helminth-induced regulatory T cells (2005, positive): “We then used the adoptive transfer system of MLNC from infected mice into sensitized, but uninfected, hosts to demonstrate that down-regulation is mediated by T cells, primarily those with the CD4 CD25 phenotype associated with T reg cells (61, 62).”
Foxp3 Expressing CD4+CD25high Regulatory T Cells Are Overrepresented in Human Metastatic Melanoma Lymph Nodes and Inhibit the Function of Infiltrating T Cells1 (2004, background): “In addition, according to what was suspected (14), Salomon’s group have nicely shown that activation of LN Treg is driven by physiological sustained presentation of tissue self-Ags in draining LNs (46).”
Tumor-specific human CD4+ regulatory T cells and their ligands: implications for immunotherapy. (2004, background): “Phenotypic and or indirectly through the secretion of anti-inflammatoryfunctional analyses demonstrated that they were antimediators such as IL-10, TGF- , or IL-4 (Levings et al.,gen-specific CD4 Treg cells expressing CD25 and 2002a; Shevach, 2002).”
Tumor cells convert immature myeloid dendritic cells into TGF-β–secreting cells inducing CD4+CD25+ regulatory T cell proliferation (2005, background): “CD4 CD25 regulatory T cells (T reg cells) were initially defined as a subpopulation of suppressor T cells that mediate immune tolerance by suppressing autoreactive T cells (1, 2).”