Regulatory T cells in the control of immune pathology

By K. Maloy, F. Powrie. Nature Immunology, 2001

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Transcriptional mechanisms underlying lymphocyte tolerance. (2002, positive): “Preferentialing PI-3 kinase and Akt and Bcl family members (Boise et IL-10 production by anergic T cells provides a link be-al., 1995; Kane et al., 2001), thus promoting proliferation tween the two current models of how peripheral tolerancerather than cell death, and at the same time it potentiates ”
Prevention of Arthritis by Interleukin 10–producing B Cells (2003, methodology): “In our model it could be argued that the production of IL-10 by B cells might induce the differentiation of Tr1 regulatory CD4+ T cells (28).”
In Vitro Generation of Interleukin 10–producing Regulatory CD4+ T Cells Is Induced by Immunosuppressive Drugs and Inhibited by T Helper Type 1 (Th1)– and Th2-inducing Cytokines (2002, background): “Clearly there are various thresholds imposed to regulate the activation of T cells, including positive and negative signals delivered to T cells from the APCs that may differ according to the previous activations encountered by the T cell (64, 65).”
IL-10-Secreting Regulatory T Cells Do Not Express Foxp3 but Have Comparable Regulatory Function to Naturally Occurring CD4+CD25+ Regulatory T Cells 1 (2004, background): “CD4 CD25 TReg protect lymphopenic mice from inflammatory bowel disease (IBD), autoimmune gastritis (15), wasting disease (4), and diabetes (16), and prevent transplant rejection (17) and immune response to tumors (18, 19).”