Pharmacological approach to the mechanisms of transcranial DC-stimulation-induced after-effects of human motor cortex excitability.

By David Liebetanz, Michael A. Nitsche, F. Tergau, Walter Paulus. Brain : a journal of neurology, 2002

1,373 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Cellular and Molecular Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/db582afc59f917a6e031ec45bc5a985e054648f4

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Citations in the corpus

Preconditioning of Low-Frequency Repetitive Transcranial Magnetic Stimulation with Transcranial Direct Current Stimulation: Evidence for Homeostatic Plasticity in the Human Motor Cortex (2004, background): “Although the exact mechanisms mediating these aftereffects remain to be clarified, there is some evidence that changes in synaptic efficacy play a part (Liebetanz et al., 2002; Iyer et al., 2003; Siebner and Rothwell, 2003).”
Effects of transcranial direct current stimulation (tDCS) on human regional cerebral blood flow (2011, background): “In contrast, Carbamazepine, which stabilizes the inactivated state of sodium channels, selectively eliminated anodal effects, suggesting that after-effects of anodal tDCS require a depolarization of membrane potentials (Liebetanz et al., 2002).”
Pharmacological Modulation of Cortical Excitability Shifts Induced by Transcranial Direct Current Stimulation in Humans (2003, background): “The fact that the voltagedependent sodium channel blocker carbamazepine (CBZ) eliminates the short-lasting after-effects induced by anodal, but not by cathodal stimulation indicates that this could be similar in the human (Liebetanz et al. 2002).”
Polarity-Sensitive Modulation of Cortical Neurotransmitters by Transcranial Stimulation (2009, background): “…anodal tDCS are mediated at least in part by a reduction in GABAergic inhibition in addition to the NMDAreceptor dependency previously demonstrated (Liebetanz et al., 2002; Nitsche et al., 2003b), while the inhibitory effects of cathodal tDCS are mediated by reduction in excitatory glutamatergic…”
Facilitation of Implicit Motor Learning by Weak Transcranial Direct Current Stimulation of the Primary Motor Cortex in the Human (2003, background): “Moreover, it was shown recently that blocking NMDA receptors prevents the induction of aftereffects (Liebetanz et al., 2002), and thus these share a certain similarity with long-term potentiation and depression, which are presumed to be important substrates for learning in the animal (Rioult-Pedotti”
Partially non‐linear stimulation intensity‐dependent effects of direct current stimulation on motor cortex excitability in humans (2013, background): “Pharmacological studies have shown that the long-lasting after-effects involve N-methyl-D-aspartate (NMDA) receptors and the GABAergic system (Liebetanz et al. 2002; Nitsche et al. 2003a, 2004b).”
Effects of non-invasive cortical stimulation on skilled motor function in chronic stroke. (2005, background): “Therefore, our finding of enhanced recruitment curves that correlate with tDCS-induced performance improvements and of reduced short-interval intracortical inhibition suggest the involvement of NMDA (Liebetanz et al., 2002; Nitsche et al., 2004a, b) and possibly GABA (Boroojerdi et al., 2001a; Chen,”
tDCS-enhanced motor and cognitive function in neurological diseases (2014, positive): “…influence recovery of lost function by its excitability-enhancing properties that possibly facilitate LTP-like processes between activated neurons (Liebetanz et al., 2002), ctDCS over the non-lesioned hemisphere will downregulate areas that are “over-active” and hamper restitution of networks in…”
The electric field in the cortex during transcranial current stimulation (2013, background): “Fax: +351 217 500 a@neuroelectrics.com salvador@fc.ul.pt (R. Salvador), rights reserved. mediated by NMDA receptors in a polarity-dependent manner (Liebetanz et al., 2002; Nitsche et al., 2003).”
A sham‐controlled, phase II trial of transcranial direct current stimulation for the treatment of central pain in traumatic spinal cord injury (2006, background): “Because carbamazepine might decrease the effects of anodal stimulation after a single session of tDCS (Liebetanz et al., 2002), we did a subanalysis in which we divided patients by use of antiepileptic drugs (carbamazepine (two patients); gabapentine (two patients) and no antiepileptic drugs (seven…”
A common polymorphism in the brain‐derived neurotrophic factor gene (BDNF) modulates human cortical plasticity and the response to rTMS (2008, background): “Similarly, disorders of metaplasticity have been postulated to underlie susceptibility to L-DOPA-induced dyskinesia in Parkinson’s disease (Picconi et al. 2003; Linazasoro, 2005).”
How does transcranial DC stimulation of the primary motor cortex alter regional neuronal activity in the human brain? (2005, background): “The conditioning effects of tDCS on corticospinal excitability are affected by drugs that change neuronal membrane excitability and are blocked by the NMDA-receptor antagonist dextromethorphan (Liebetanz et al., 2002).”