Facilitation of Implicit Motor Learning by Weak Transcranial Direct Current Stimulation of the Primary Motor Cortex in the Human

By Michael A. Nitsche, Astrid Schauenburg, N. Lang, David Liebetanz, C. Exner, Walter Paulus, F. Tergau. Journal of Cognitive Neuroscience, 2003

1,032 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/10fecc1a97367bc408cffb98e74735c5b7beb790

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Citations in the corpus

Shaping the effects of transcranial direct current stimulation of the human motor cortex. (2007, background): “In experiment 1, the currents flowed continuously for 4 s (excitability shifts during tDCS, experiment 1a) or 7 min (short-lasting aftereffects, experiment 1b), to cover both intra-and aftereffects of tDCS (Nitsche and Paulus 2000, 2001; Nitsche et al. 2003a).”
Gyri –precise head model of transcranial DC stimulation: Improved spatial focality using a ring electrode versus conventional rectangular pad (2009, neutral): “Curr Treat Options Neurol 2008; 10(5):377 385.”
Anodal transcranial direct current stimulation of prefrontal cortex enhances working memory (2005, background): “…of excitability-enhancing anodal DC stimulation on simple reaction times and implicit motor learning when the primary motor cortex was stimulated (Nitsche et al. 2003c), as well as improved learning of a visuo-motor coordination task by stimulation of the primary motor area or the visual area V5…”
Effects of non-invasive cortical stimulation on skilled motor function in chronic stroke. (2005, background): “In both sessions, currents were turned off slowly over a few seconds, a procedure that does not elicit perceptions (Nitsche et al., 2003c) and that was implemented out of the field of view of the patients.”
A sham‐controlled, phase II trial of transcranial direct current stimulation for the treatment of central pain in traumatic spinal cord injury (2006, background): “…other safety studies using related stimulation protocols, where no change of serum neurone specific enolase concentration – a sensitive marker of neuronal damage, no disturbances of the blood–brain-barrier and no cerebral edemas were found (Nitsche and Paulus, 2001; Nitsche et al., 2003a, 2004).”
The Role of GABA in Human Motor Learning (2011, positive): “As ameasure of GABA responsiveness, we used magnetic resonance spectroscopy (MRS) to quantify changes in GABA concentration following anodal transcranial direct current stimulation (tDCS), a noninvasive technique that decreases GABA within the motor cortex [5], increases cortical excitability [8], a”
Cognitive Enhancement: Methods, Ethics, Regulatory Challenges (2009, neutral): “TMS in suitable areas has also been found beneﬁcial in a motor task (Buteﬁsch et al. 2004), motor learning (Nitsche et al. 2003), visuo-motor coordination tasks (Antal et al. 2004a, b), working memory (Fregni et al. 2005), ﬁnger sequence tapping (Kobayashi et al. 2004), classiﬁcation (Kincses et…”
Therapeutic effects of non-invasive brain stimulation with direct currents (tDCS) in neuropsychiatric diseases (2014, neutral): “The resulting plasticity involves glutamatergic 96 synapses, and is calcium-dependent (Nitsche et al., 2003a, 2004b; 97 Stefan et al., 2002; Wolters et al., 2003).”
Direct current stimulation promotes BDNF-dependent synaptic plasticity: Potential implications for motor learning (2010, positive): “It has also been presumed that tDCS strengthens synaptic connections (Nitsche et al., 2003b, 2004; Cheeran et al., 2008), through a mechanism similar to long-term potentiation (LTP), a cellular correlate of learning and memory (Bliss and Collingridge, 1993; Martin et al., 2000; Rioult-Pedotti et…”
Noninvasive cortical stimulation enhances motor skill acquisition over multiple days through an effect on consolidation (2009, background): “Three previous studies have shown enhancement of motor learning in a single session using anodal tDCS in healthy subjects (15, 16, 18).”
Battery powered thought: Enhancement of attention, learning, and memory in healthy adults using transcranial direct current stimulation (2014, positive): “Human studies confirm these results; the administration of drugs that alter neuronal sodium and calcium currentsmodulates the acute effects of tDCS (Liebetanz et al., 2002; Nitsche et al., 2003a).”
Physiological and modeling evidence for focal transcranial electrical brain stimulation in humans: A basis for high-definition tDCS (2013, background): “However, evoked potential data provides evidence that corticomotor excitability can change directly below the electrode pad (Nitsche and Paulus, 2000), and subsequent studies have shown motor behavioral improvement with this montage (Hummel et al., 2006; Nitsche et al., 2003).”
How does transcranial DC stimulation of the primary motor cortex alter regional neuronal activity in the human brain? (2005, background): “Consistent with animal data, these changes in excitability persist beyond the time of stimulation if tDCS is given for more than 3 min (Nitsche & Paulus, 2000) and remain stable for at least an hour if tDCS is given for ‡ 10 min (Nitsche & Paulus, 2001; Nitsche et al., 2003a).”
Pharmacological Modulation of Cortical Excitability Shifts Induced by Transcranial Direct Current Stimulation in Humans (2003, background): “For healthy human subjects, it has already been shown that tDCS can modulate neuroplastic changes (Rosenkranz et al. 2000; Nitsche et al. 2003b).”
Noninvasive Brain Stimulation Improves Language Learning (2008, background): “Anodal tDCS can increase corticomotoneuronal excitability ( Nitsche & Paulus, 2001 ) and improve learning in implicit motor (Nitsche, Schauenburg, et al., 2003), visuomotor (Antal et al., 2004), and probabilistic classification (Kincses, Antal, Nitsche, Bartfai, & Paulus, 2004) tasks in healthy volu”