Pharmacological Modulation of Cortical Excitability Shifts Induced by Transcranial Direct Current Stimulation in Humans

By Michael A. Nitsche, K. Fricke, U. Henschke, A. Schlitterlau, David Liebetanz, N. Lang, S. Henning, F. Tergau, Walter Paulus. Journal of Physiology, 2003

1,515 citations recorded by the source corpus.

Subfields: Neurology, Surgery

View Paper: https://www.semanticscholar.org/paper/56a8b46ad8792bc4158192bdc6f0e652fca50381

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Neurology

1. Agnes Flöel
2. Alvaro Pascual-Leone
3. Michael A. Nitsche
4. Leonardo G. Cohen
5. John C. Rothwell
6. Walter Paulus
7. Felipe Fregni
8. Ulf Ziemann

In Surgery

1. Michael A. Nitsche
2. Walter Paulus
3. Min-Fang Kuo
4. Agnes Flöel
5. Raja Parasuraman

Citations in the corpus

• tDCS-enhanced motor and cognitive function in neurological diseases (2014, positive): “…polarity, neuronal firing rates increase or decrease, presumably due to DC-induced changes in resting membrane potentials (Liebetanz et al., 2002; Nitsche et al., 2003b), with anodal tDCS in most settings increasing, and cathodal tDCS decreasing motor-cortical excitability (Nitsche and Paulus,…”
• Effects of transcranial direct current stimulation (tDCS) on human regional cerebral blood flow (2011, background): “…(tDCS) on human regional cerebral blood flow, NeuroImage (2011), doi:10.1016/j.neuroimage.2011.06.018 been observed in implicit motor learning (Nitsche et al., 2003a, 2003b, 2003c), sensorimotor skills (Reis et al., 2009; Vines et al., 2006a, 2006b, 2008a, 2008b), visuomotor coordination…”
• Polarity-Sensitive Modulation of Cortical Neurotransmitters by Transcranial Stimulation (2009, background): “…mediated at least in part by a reduction in GABAergic inhibition in addition to the NMDAreceptor dependency previously demonstrated (Liebetanz et al., 2002; Nitsche et al., 2003b), while the inhibitory effects of cathodal tDCS are mediated by reduction in excitatory glutamatergic neurotransmission.”
• Dissociating the roles of the cerebellum and motor cortex during adaptive learning: the motor cortex retains what the cerebellum learns. (2011, background): “2009) with the effects lasting approximately 30 min after the cessation of stimulation (Nitsche et al. 2003; Galea et al. 2009).”
• Battery powered thought: Enhancement of attention, learning, and memory in healthy adults using transcranial direct current stimulation (2014, positive): “Human studies confirm these results; the administration of drugs that alter neuronal sodium and calcium currentsmodulates the acute effects of tDCS (Liebetanz et al., 2002; Nitsche et al., 2003a).”
• The electric field in the cortex during transcranial current stimulation (2013, background): “mediated by NMDA receptors in a polarity-dependent manner (Liebetanz et al., 2002; Nitsche et al., 2003).”
• Determinants of the induction of cortical plasticity by non‐invasive brain stimulation in healthy subjects (2010, methodology): “Anodal tDCS of motor cortex typically induces an LTP-like increase in MEP amplitude while cathodal tDCS induces an LTD-like decrease (Nitsche & Paulus, 2001; Nitsche et al. 2003).”
• Clinical Research with Transcranial Direct Current Stimulation (tDCS): Challenges and Future Directions (2011, positive): “the stimulation duration as opposed to the current density.(7,27,35,37) Short applications (ie, seconds to a few minutes) of anodal/cathodal tDCS result in excitability shifts during stimulation but no after-effects.”
• Therapeutic effects of non-invasive brain stimulation with direct currents (tDCS) in neuropsychiatric diseases (2014, positive): “The resulting plasticity involves glutamatergic 96 synapses, and is calcium-dependent (Nitsche et al., 2003a, 2004b; 97 Stefan et al., 2002; Wolters et al., 2003).”
• Direct current stimulation promotes BDNF-dependent synaptic plasticity: Potential implications for motor learning (2010, positive): “It has also been presumed that tDCS strengthens synaptic connections (Nitsche et al., 2003b, 2004; Cheeran et al., 2008), through a mechanism similar to long-term potentiation (LTP), a cellular correlate of learning and memory (Bliss and Collingridge, 1993; Martin et al., 2000; Rioult-Pedotti et…”
• Partially non‐linear stimulation intensity‐dependent effects of direct current stimulation on motor cortex excitability in humans (2013, methodology): “Accordingly, the after-effects of tDCS are caused by calcium-dependent mechanisms (Nitsche et al. 2003a).”