Mitochondria: More Than Just a Powerhouse

By H. McBride, Margaret Neuspiel, S. Wasiak. Current Biology, 2006

1,951 citations recorded by the source corpus.

Subfields: Clinical Biochemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/d9fa84b322a2e3fbd81ed95e0f86711c15d3068e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Clinical Biochemistry

1. K. Mihara
2. D. Seol
3. M. Guo
4. M. Dodson
5. Seon-Yong Jeong
6. R. Youle
7. M. Liesa
8. H. Sesaki

In Molecular Biology

1. R. Youle
2. M. Liesa
3. Chunxin Wang
4. K. Mihara
5. N. Wakabayashi
6. D. Seol
7. Seon-Yong Jeong
8. Megan M. Cleland

Citations in the corpus

• Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells (2010, background): “mitochondrial networks, and this dynamic morphology is essential for normal mitochondrial and cellular functions (Karbowski and Youle, 2003; Okamoto and Shaw, 2005; Chan, 2006; McBride et al., 2006; Cerveny et al., 2007b; Hoppins et al., 2007; Benard and Karbowski, 2009).”
• Crosstalk between mitochondria and NADPH oxidases (2011, background): “A new concept is emerging that mitochondria are more than just “ATP cows” [37,38], and ROS production by mitochondria is a part of”
• Mitochondrial dynamics in mammalian health and disease. (2009, background): “Although there are several reports that relate NF B signaling with mitochondria (203, 264), MULAN is the first protein that directly links NF B and regulation of mitochondrial morphology and distribution.”
• The role of mitochondria in apoptosis. (2008, background): “(2) Drp1-dependent mitochondrial fission promoted by Bax translocation is responsible for MOMP.”
• Pink1, Parkin, DJ-1 and mitochondrial dysfunction in Parkinson's disease. (2007, background): “Which aspects of mitochondrial function rely on Pink1 and Parkin? Mitochondria have crucial roles in multiple cellular processes, including ATP production, regulation of cell death, Ca homeostasis and cellular signaling [37].”
• Surface chemistry and aspect ratio mediated cellular uptake of Au nanorods. (2010, neutral): “Based upon the above results, the mitochondrial damage may explain the changes of cell cycle and increased apoptosis since mitochondria play key roles in the regulation of cell cycle and apoptosis [50,51].”
• The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice (2009, background): “…are highly dynamic organelles that continuously fuse and divide within cells (Karbowski and Youle, 2003; Osteryoung and Nunnari, 2003; Rube and van der Bliek, 2004; Okamoto and Shaw, 2005; Anesti and Scorrano, 2006; Chan, 2006; McBride et al., 2006; Cerveny et al., 2007a; Hoppins et al., 2007).”
• Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria (2008, neutral): “This equilibrium is tightly regulated to ensure proper mitochondrial content in daughter cells and is impaired during apoptosis, when mitochondria fragment and cluster in the perinuclear region (2).”