Pink1, Parkin, DJ-1 and mitochondrial dysfunction in Parkinson's disease.

By M. Dodson, M. Guo. 2007

284 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology, Neurology, Computational Biology & Bioinformatics, Neuroscience

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. M. Komatsu

In Molecular Biology

1. M. Komatsu
2. Keiji Tanaka
3. N. Matsuda
4. A. Gorman
5. S. Kawajiri
6. Simone Fulda
7. Afshin Samali

In Neurology

1. M. Komatsu
2. N. Matsuda
3. S. Kawajiri

Citations in the corpus

• The Role of Oxidative Stress in Parkinson’s Disease (2013, unknown): “to demonstrate this rescue effect [329, 334].”
• Cellular Stress Responses: Cell Survival and Cell Death (2010, background): “In addition, several of these genes, including parkin, PINK1, DJ-1, and Omi/Htra2 are linked to the mitochondria and may have roles in mitochondrial function and resistance to oxidative stress [254].”
• Human iPSC-based Modeling of Late-Onset Disease via Progerin-induced Aging (2013, unknown): “PINK1 and Parkin are thought to act in a common pathway to promote the autophagic degradation of damaged mitochondria (Dodson and Guo, 2007), in addition to the unique functions of Parkin in the ubiquitin-proteasome pathway (Shimura et al.”
• Oxidative Stress, Mitochondrial Dysfunction, and Aging (2011, background): “Genetic studies of PINK1 and PARKIN further support the role of mitochondrial dysfunction in pathogenesis of PD [179, 180].”
• PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy (2010, background): “PINK1 functions in mitochondrial maintenance, suggesting that mito chondrial integrity is another key factor in disease patho genesis (Dodson and Guo, 2007; Schapira, 2008).”