Subpopulations of proliferating cells of the adult hippocampus respond differently to physiologic neurogenic stimuli

By Golo Kronenberg, K. Reuter, B. Steiner, M. Brandt, Sebastian Jessberger, Masahiro Yamaguchi, Gerd Kempermann. The Journal of comparative neurology, 2003

694 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/d9570bd5cef4c7f0b30ecf3527d2951290133853

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Citations in the corpus

Microglia shape adult hippocampal neurogenesis through apoptosis-coupled phagocytosis (2010, background): “Based on published data of BrdU decay (Kempermann et al., 2004; Kronenberg et al., 2003; Mandyam et al., 2007), we hypothesized that newborn cells undergo apoptosis mostly during an early critical period and that the apoptotic debris is removed from the SGZ neurogenic niche by microglia.”
Brain‐derived neurotrophic factor (BDNF) is required for the enhancement of hippocampal neurogenesis following environmental enrichment (2006, background): “2000), even if effects on the proliferation of subgranular progenitor cells have also been reported (Kempermann et al., 1998; Kronenberg et al., 2003).”
Environmental enrichment and neurogenesis: from mice to humans (2015, background): “Despite variable results when using EE-only without a running wheel [5,6], a number of studies have shown that EE-only is capable of inducing neurogenesis [3 ,9,10 ,11,12 ,13,14 ].”
Quiescent and active hippocampal neural stem cells with distinct morphologies respond selectively to physiological and pathological stimuli and aging. (2010, background): “Physical activity enhances generation of DG neurons by inducing proliferation of radial Sox2 progenitor cells and neuronal precursors (Kronenberg et al., 2003; Steiner et al., 2008; Suh et al., 2007; van Praag et al., 1999b).”
Adult neurogenesis and cellular brain repair with neural progenitors, precursors and stem cells (2006, background): “Type 2 cells can be subdivided into DCX-positive 'type 2a' and DCX-negative 'type 2b' cells (Kronenberg et al. 2003).”
Milestones of neuronal development in the adult hippocampus. (2004, methodology): “However, they account for only 5% of cell divisions among the nestin-expressing cells of the SGZ [20, 25 ].”
Type‐2 cells as link between glial and neuronal lineage in adult hippocampal neurogenesis (2006, background): “Whereas proliferation of the nestin-GFP-positive radial cells was unaffected (Kronenberg et al., 2003), the number of dividing GFAP-positive S100b-negative cells increased.”
Doublecortin expression levels in adult brain reflect neurogenesis (2005, background): “AD, Alzheimer’s disease; BrdU, bromodeoxyuridine; CNS, central nervous system; DCX, doublecortin; DRG, dorsal root ganglion; EGFP, enhanced green fluorescent protein; GFP, green fluorescent protein; SVZ, subventricular zone; TBS, Tris-buffered saline.”
Adult neurogenesis: from precursors to network and physiology. (2005, methodology): “On the basis of the analysis of nestin-promoter GFP transgenic mice, two classes of cells have been identified: type 1 cells (GFAP , S100 , DCX , PSA-NCAM ), which correspond to type B cells, and are the putative stem cell, and type 2 cells (GFAP , S100 , DCX , PSA-NCAM ) supposed to be the type D c”
Visualization and genetic manipulation of adult neurogenesis using transgenic mice (2011, background): “These cells arise from the slow-dividing radial-glial-type stem cells (Type 1) that give rise to fast-dividing and multiple transient amplifying progenitors (Type 2a, 2b and 3; Kronenberg et al., 2003; Kempermann et al., 2004).”
The Timing of Differentiation of Adult Hippocampal Neurons Is Crucial for Spatial Memory (2008, background): “A further group of progenitor cells lacks nestin but expresses DCX (type-3; [9]).”
Neurogenesis in the Adult Hippocampus. (2015, background): “Type 2 cells respond to physiological stimuli, such as voluntary wheel running (Kronenberg et al. 2003), or pharmacological stimulation via serotonin-dependent mechanisms (Encinas et al.”
Signaling through BMPR-IA regulates quiescence and long-term activity of neural stem cells in the adult hippocampus. (2010, background): “…rarely divide whereas SOX2 + nonradial cells appear to cycle relatively more often; consequently, it has been suggested that the radial cell population constitutes a stem cell reservoir (Seri et al., 2001, 2004; Filippov et al., 2003; Fukuda et al., 2003; Kronenberg et al., 2003; Suh et al., 2007).”
Reversible effect of X‐irradiation on proliferation, neurogenesis, and cell death in the dentate gyrus of adult mice (2007, neutral): “In the adult mouse dentate gyrus, 25% of the dividing cells are DCX-positive 2 h after a single pulse of 5-bromo-20deoxyuridine (BrdU), representing dividing precursors of neuronal lineage (Kronenberg et al., 2003).”
Experience-Specific Functional Modification of the Dentate Gyrus through Adult Neurogenesis: A Critical Period during an Immature Stage (2007, background): “This same study suggested that this increase could be attributed to increased survival, but later studies have indicated that the enriched environment also affects cell proliferation (Kempermann et al., 1998; Kronenberg et al., 2003).”
Long-Term Potentiation Enhances Neurogenesis in the Adult Dentate Gyrus (2006, background): “1d), an early expressed neural lineage-specific homeobox transcription factor selective to DGCs (Kronenberg et al., 2003).”
Modification of hippocampal circuitry by adult neurogenesis (2012, background): “Interestingly, the proliferation of Type II cells is subject to activitydependent regulation through either physiological stimuli such as voluntary wheel running (Kronenberg et al., 2003) or pharmacological stimulation, such as antidepressant treatment (Encinas et al., 2006).”
Division-Coupled Astrocytic Differentiation and Age-Related Depletion of Neural Stem Cells in the Adult Hippocampus (2011, background): “QNPs encompass the majority of neuron-producing stem cell activity in the adult DG and overlap to a large degree with other varieties of hippocampal stem cells which have been identified structurally, functionally, or by expression of other reporters (Eckenhoff and Rakic, 1984; Garcia et al., 2004; ”