Brain‐derived neurotrophic factor (BDNF) is required for the enhancement of hippocampal neurogenesis following environmental enrichment

By C. Rossi, A. Angelucci, L. Costantin, C. Braschi, M. Mazzantini, Francesco Babbini, M. E. Fabbri, L. Tessarollo, L. Maffei, N. Berardi and 1 more. European Journal of Neuroscience, 2006

618 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience

View Paper: https://www.semanticscholar.org/paper/9426d00d9c1ed526015ab3b4310d476ab152991b

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In Cellular and Molecular Neuroscience

In Developmental Neuroscience

Citations in the corpus

The role of adult hippocampal neurogenesis in brain health and disease (2018, background): “A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript Table 1 Signals regulating adult hippocampal neurogenesis Stages Regulators Secreted factors and downstream effectors (Morphogens, growth fa”
Interaction between BDNF and Serotonin: Role in Mood Disorders (2008, background): “An additional study found evidence for the dependence of BDNF on the enhancement of hippocampal neurogenesis that is observed following environmental enrichment (Rossi et al, 2006).”
Modification of hippocampal circuitry by adult neurogenesis (2012, background): “Furthermore, conditional ablation of TrkB, the high-affinity receptor for BDNF, in both embryonic and adult-born NSCs led to an impairment of hippocampal neurogenesis and prevented behavioral improvements induced by chronic antidepressant administration or wheel-running (Rossi et al., 2006; Babu et ”
BDNF: A Key Factor with Multipotent Impact on Brain Signaling and Synaptic Plasticity (2017, background): “Neurogenesis could be induced by environmental enrichment (Kempermann et al. 1997; Rossi et al. 2006), hippocampus-dependent learning (Gould 1999), and physical exercise (Aimone et al.”
Environmental enrichment and neurogenesis: from mice to humans (2015, background): “Both EE exposure and voluntary exercise can induce the expression of BDNF [29–30,31 ,32], a neurotrophin that supports survival, differentiation and neurite growth in existing neurons.”
Adult neurogenesis and the olfactory system. (2009, background): “Neurotrophic factors, particularly BDNF and VEGF, are important for the neurogenic mechanisms of antidepressants and environment (Rossi et al., 2006; Castren et al., 2007; Warner-Schmidt and Duman, 2007).”
Mechanisms and functional implications of adult neurogenesis. (2008, neutral): “Moreover, an enriched environment fails to enhance the survival of newborn cells in BDNF+/ mice (Rossi et al., 2006).”
TrkB regulates hippocampal neurogenesis and governs sensitivity to antidepressive treatment (2008, background): “BDNF germline heterozygous mice have been reported to have decreased (Lee et al., 2000) or increased (Sairanen et al., 2005) proliferation, as well as decreased (Sairanen et al., 2005) or normal (Rossi et al., 2006). long-term neurogenesis.”