Long-Term Potentiation Enhances Neurogenesis in the Adult Dentate Gyrus

By E. Bruel-Jungerman, S. Davis, C. Rampon, S. Laroche. 2006

313 citations recorded by the source corpus.

Activity-dependent synaptic plasticity and neurogenesis are two forms of brain plasticity that can participate in functional remodeling of neural networks during the formation of memories. We examined whether long-term potentiation (LTP) of excitatory synaptic transmission, a well characterized form of synaptic plasticity believed to play a critical role in memory formation, can regulate the rate of neurogenesis in the adult rat dentate gyrus in vivo. We first show that induction of LTP at medial perforant path–granule cell synapses stimulates the proliferation of progenitor cells in the dentate gyrus with a consequential long-term persistence of a larger population of surviving newborn cells. Using protocols to examine the effect of LTP on survival, we next show that LTP induction promotes survival of 1- to 2-week-old dentate granule cells. In no case did LTP appear to affect neuronal differentiation. Finally, we show that LTP induces expression of the plasticity-related transcription factor Zif268 in a substantial fraction of 2-week-old but not 1-week-old neurons, suggesting the prosurvival effect of LTP can be observed in the absence of LTP-mediated Zif268 induction in newborn cells. Our results indicate that electrically induced LTP in the dentate gyrus in vivo provides a cellular/molecular environment that favors both proliferation and survival of adult-generated neurons.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience

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Citations in the corpus

New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? (2010, background): “For example, induction of LTP in the dentate gyrus by high-frequency stimulation of the perforant pathway can increase the proliferation of NPCs in the SGZ and enhance the survival of adult-born DGCs at 1–2 weeks of ag”
Spatial Learning Depends on Both the Addition and Removal of New Hippocampal Neurons (2007, background): “In favor of this hypothesis, it has been shown that enhanced synaptic activity enhances cell survival [36].”
Modification of hippocampal circuitry by adult neurogenesis (2012, background): “Similarly, LTP induction in the hippocampus, which is thought to be associated with the mechanism for memory formation and retention, has been shown to increase dentate progenitor proliferation and promote survival of new neurons of 1–2 weeks of cell age (Bruel-Jungerman et al., 2006).”
Adult neurogenesis and the olfactory system. (2009, background): “Induction of LTP increases proliferation of DG progenitors, and enhances survival of 1–2 week old DG neurons, but has no effect on neuronal differentiation (Bruel-Jungerman et al., 2006).”
Adult-born hippocampal neurons are more numerous, faster-maturing and more involved in behavior in rats than in mice (2009, result): “The small number of electrophysiological studies of young neurons in rats are consistent with our findings, as they show significant excitatory synaptic input, long-term potentiation and IEG expression in cells ≤ 3 weeks old (Snyder et al., 2001; Schmidt-Hieber et al., 2004; Bruel-Jungerman et al., ”
Preferential incorporation of adult-generated granule cells into spatial memory networks in the dentate gyrus (2007, result): “Previous studies used similar immunohistochemical approaches to show that adult-generated granule cells can be activated by a variety of stimulation, including high-frequency electrical perforant path stimulatio”
Recruitment of adult-generated neurons into functional hippocampal networks contributes to updating and strengthening of spatial memory (2009, background): “The second week after their birth, adult-generated hippocampal neurons express Zif268 in response to artificially induced long-term potentiation of excitatory synaptic transmission, suggesting that they are prone to be recruited into memory networks (10).”
Synaptic integration and plasticity of new neurons in the adult hippocampus (2008, background): “On the other hand, induction of long-term potentiation at the glutamatergic medial perforant path–granule cell synapses promotes the proliferation of adult neural progenitors and survival of newborn neurons in an NMDAR-dependent fashion (Bruel-Jungerman et al. 2006; Chun et al. 2006).”
Brain-derived Neurotrophic Factor Promotes Differentiation and Maturation of Adult-born Neurons Through GABAergic Transmission (2012, background): “Two such genes, Arc and Zif268, are induced by activity in newly generated adult-born dentate gyrus neurons (Bruel-Jungerman et al., 2006; Kee et al., 2007).”
Persistence of long-term memory storage requires a late protein synthesis- and BDNF- dependent phase in the hippocampus. (2007, unknown): “, 2006), and recent works have also involved Zif268 in memory processing (Bozon et al., 2003; Bruel-Jungerman et al., 2006; Jones et al., 2001; Lee et al., 2004; Malkani et al., 2004; Valjent et al., 2006).”
Structural Plasticity and Hippocampal Function (2010, result): “…neurogenesis may be promoted by synaptic plasticity during learning, an idea that is consistent with electrophysiological data showing that enhanced synaptic activity associated with long-term potentiation (LTP) increases cell proliferation and cell survival (Bruel-Jungerman et al. 2006).”
Adult neurogenesis and the plasticity of the dentate gyrus network (2011, background): “In fact, in vivo induction of LTP in medial perforant path synapses of adult rats was shown to increase proliferation and survival of neurons born a few days after LTP induction (Bruel-Jungerman et al., 2006).”