Type‐2 cells as link between glial and neuronal lineage in adult hippocampal neurogenesis

By B. Steiner, F. Klempin, Liping Wang, M. Kott, Helmut Kettenmann, Gerd Kempermann. 2006

368 citations recorded by the source corpus.

Subfields: Cancer Research, Developmental Neuroscience, Neurology

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Citations in the corpus

Prospero-related homeobox 1 gene (Prox1) is regulated by canonical Wnt signaling and has a stage-specific role in adult hippocampal neurogenesis (2011, background): “Prox1 expressionwas also high in doublecortin (DCX)- and NeuroD1-expressing cells, two markers for newborn neuronal cells in the adult DG (25, 26).”
The Chemokine Stromal Cell-Derived Factor-1 Regulates GABAergic Inputs to Neural Progenitors in the Postnatal Dentate Gyrus (2008, background): “Although this cell population is certainly heterogeneous (Steiner et al. 2006), it does contain the “transiently amplifying population” whose proliferation may be susceptible to external influences.”
Reversible effect of X‐irradiation on proliferation, neurogenesis, and cell death in the dentate gyrus of adult mice (2007, positive): “Although the duration of the cell cycle is estimated to be 12–14 h in young adult mice (Hayes and Nowakowski, 2002), the cell cycle of the quiescent population lasts up to 1 week (Steiner et al., 2006), which may explain the time required to restore the proliferating cell pool.”
The Glial Nature of Embryonic and Adult Neural Stem Cells (2009, background): “Unlike other astrocytes in the SGZ that express only GFAP, these cells express both GFAP and Nestin (Seri et al. 2004, Steiner et al. 2006).”
Adult Neurogenesis in the Hippocampus: From Stem Cells to Behavior. (2016, positive): “Sox2 is highly Cell 167, November 3, 2016 901 expressed in type 1 and type 2a cells and controls the multipotency and proliferative capacities of NSCs (Favaro et al., 2009; Steiner et al., 2006).”
Sox1 marks an activated neural stem/progenitor cell in the hippocampus (2012, background): “SOX2 marks both radial astrocytes (also known as type 1 cells) and early progenitor cells (also known as type 2a cells) within the adult dentate gyrus (Steiner et al., 2006).”
Visualization and genetic manipulation of adult neurogenesis using transgenic mice (2011, background): “Most of the nestin reporter mice label Type 2a and 2b cells, which represent the fast dividing early progenitor cells (Jessberger et al., 2005; Steiner et al., 2006; Lagace et al., 2007; Arguello et al., 2008); however, at least one nestin reporter (Yu et al., 2008) has no Type 2b (DCXexpressing)…”
Murine Features of Neurogenesis in the Human Hippocampus across the Lifespan from 0 to 100 Years (2010, methodology): “Based on our previous studies in rodents and reports from the literature we next focused on nestin [37,38], PSA-NCAM [39], NeuroD, Sox2 [40], Prox1 [41], Tuc4 [39], b-III-tubulin, NeuN,”
Modification of hippocampal circuitry by adult neurogenesis (2012, background): “Morphologically, horizontal cellular processes are prominent in these progenitor cells (Fukuda et al., 2003; Steiner et al., 2006).”
The Timing of Differentiation of Adult Hippocampal Neurons Is Crucial for Spatial Memory (2008, background): “These new neurons, which increased in number by activation of the PC3 transgene, were also positive for NeuroD1 (Brduþ/NeuroD1þ/NeuNþ; Figure 1I), whose expression begins in type-2b progenitor cells, is maintained in post-mitotic hippocampal granule neurons, and is required for differentiation [46,4”
Quiescent and active hippocampal neural stem cells with distinct morphologies respond selectively to physiological and pathological stimuli and aging. (2010, background): “In the subgranular zone (SGZ) of the adult hippocampal dentate gyrus (DG), NSCs (also referred to as Type-1 cells) produce intermediate progenitor cells (IPs, Type-2a cells) that retain expression of stem/progenitor markers including the transcription factor Sox2 (Kempermann et al., 2004; Seri et al”
GABA-CREB signalling regulates maturation and survival of newly generated neurons in the adult hippocampus (2009, background): “…marker, Ki67, the immature dendritic growth- associated neuronal protein, DCX (Brown et al., 2003; Cohen et al., 2008), the proneural basic helix-loop-helix (bHLH) transcription factor, NeuroD (Steiner et al., 2006; Seki et al., 2007), and the mature dentate granule neuron protein, calbindin.”