Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease

By B. Boland, Asok Kumar, Sooyeon Lee, F. Platt, J. Wegiel, W. H. Yu, Ralph A. Nixon. Journal of Neuroscience, 2008

1,097 citations recorded by the source corpus.

Subfields: Cell Biology, Epidemiology, Physiology

View Paper: https://www.semanticscholar.org/paper/d8b90c58e3ea9e7bc177a84159c04451895c57aa

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

In Epidemiology

In Physiology

Citations in the corpus

Autophagy: a lysosomal degradation pathway with a central role in health and disease. (2009, background): “The primary cause for the increased accumulation of autophagic compartments in Alzheimer's disease was recently suggested to be their retarded maturation to autolysosomes [144].”
Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities. (2017, positive): “Aβ may be degraded by autophagy and upregulation of autophagy has been shown to reduce Aβ levels in a number of systems (Boland et al., 2008; Spilman et al., 2010; Tian et al., 2011; Vingtdeux et al., 2011).”
The pathways of mitophagy for quality control and clearance of mitochondria (2012, background): “At basal levels, neuronal autophagy is highly efficient, and as a result, autophagosomes are rarely observed in neurons.(105) In fact, multiple lines of evidence suggest that regulation of autophagy in neurons is distinct from other cell types.”
Autophagy in the Cellular Energetic Balance (2011, positive): “, 2006); however, the rapid clearance of autophagosomes limits the number of them visible at a given time (Boland et al., 2008).”
Mitophagy and Alzheimer’s disease: cellular and molecular mechanisms (2017, background): “Autophagosome accumulation in mouse cortical neurons occurs following oxidative stress, a condition associated with AD [68].”
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (2012, neutral): “another frequently used inhibitor, leupeptin, requires at least 6 h pre-incubation.(59) Moreover, pepstatin A is membrane”
Autophagy gone awry in neurodegenerative diseases (2010, neutral): “20 ), including a growing number of neurological disorders such as Alzheimer's disease, Parkinson's disease, Huntington's disease and amyotrophic lateral sclerosis (ALS”
Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein (2017, background): “Importantly, treating cells with 10 mM NCT-504 and 100 nM bafilomycin A1 for two hours and six hours resulted in a 38% and 51% increase in LC3-II levels respectively compared with bafilomycin A1 treatment alone, which indicates that NCT-504 induces autophagosome formation.”