Autophagy in the Cellular Energetic Balance
By Rajat Singh, A. Cuervo. Cell Metabolism, 2011
767 citations recorded by the source corpus.
Autophagy mediates the degradation of cellular components in lysosomes, assuring removal of altered or dysfunctional proteins and organelles. Autophagy is not only activated in response to cellular damage, but in fact, one of its strongest and better-characterized stimuli is starvation. Activation of autophagy when nutrients are scarce allows cells to reutilize their own constituents for energy. Besides protein breakdown, autophagy also contributes to the mobilization of diverse cellular energy stores. This recently discovered interplay between autophagy and lipid and carbohydrate metabolism reveals the existence of a dynamic feedback between autophagy and cellular energy balance.
Subfields: Biochemistry, Epidemiology, Pharmacology
View Paper: https://www.semanticscholar.org/paper/8bd3d4476fa85db7e7865c53c3f0db35813baba1
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Citations in the corpus
- A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB (2012, methodology): “Therefore, we used kinase inhibitors Torin 1 and Torin2, which belong to a novel class of molecules that target the mTOR catalytic site, thereby completely inhibiting mTOR activity (Feldman et al, 2009; Garcia-Martinez et al, 2009; Thoreen et al, 2009).”
- Autophagy and multidrug resistance in cancer (2017, background): “During fusion with the lysosome, the outer membrane is cleaved and recycled by Atg4, while LC3-PE associated with the inner membrane is degraded by lysosomal proteases along with the cargo of the autophagosome, thus recycling amino acids, fatty acids, and nucleotides [25].”
- Promoting Health and Longevity through Diet: from Model Organisms to Humans (2015, unknown): “, 2014); improved chaperone-mediated protein homeostasis and cellular turnover processes, including autophagy (Singh and Cuervo, 2011); and increases in various forms of stress resistance (Hine et al.”
- Regulation of mTORC1 and its impact on gene expression at a glance (2013, background): “Control of lysosome biogenesis by the mTORC1–TFEB axis Lysosomes are organelles that contribute to cellular homeostasis by regulating a plethora of physiological processes, including cellular clearance, lipid homeostasis, energy metabolism and pathogen defense (reviewed by Singh and Cuervo, 2011).”