Peroxynitrite: biochemistry, pathophysiology and development of therapeutics

By C. Szabó, H. Ischiropoulos, Rafael Radi. Nature reviews. Drug discovery, 2007

2,021 citations recorded by the source corpus.

Subfields: Biophysics, Immunology, Physiology

View Paper: https://www.semanticscholar.org/paper/d8685aad7d0f087a00f465bbbc7290b52ead8d6a

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Citations in the corpus

Endothelial Dysfunction and Diabetes: Effects on Angiogenesis, Vascular Remodeling, and Wound Healing (2012, background): “Studies aimed at combination therapies could prove beneficial to enhance protection against vascular complications during diabetes.”
Tumor‐induced tolerance and immune suppression by myeloid derived suppressor cells (2008, background): “Peroxynitrites are no longer considered simply toxic byproducts but are now viewed as potential intracellular and intercellular messengers, because they can diffuse through cell membranes and induce post-translational protein modifications by nitrating protein-associated tyrosine, cysteine, methioni”
Chemistry and biology of reactive oxygen species in signaling or stress responses (2011, background): “and can react with ROS to form oxidants such as peroxynitrit”
The role of oxidative stress during inflammatory processes (2013, background): “The underlying reasons remain thus far unclear, but it is likely that the particular experimental conditions explain, at least partly, these contrasted results: these include notably the specific cell type studied, the particular ROS or RNS studied, the concentration of the oxidants used, as well as”
Chemical biology of peroxynitrite: kinetics, diffusion, and radicals. (2009, background): “, via thiol oxidation of key transcription factors or enzymes (10, 98).”
Upsides and Downsides of Reactive Oxygen Species for Cancer: The Roles of Reactive Oxygen Species in Tumorigenesis, Prevention, and Therapy (2012, neutral): “Superoxide can also react with the reactive nitric oxide (NO $ ) to form peroxynitrite (ONOO - ) (295).”
Biological Activities of Reactive Oxygen and Nitrogen Species: Oxidative Stress versus Signal Transduction (2015, background): “A few more publications can be found on peroxynitrite-mediated signaling (reviewed in [80,81]).”
Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal (2014, background): “Lipid hydroperoxides can also react with peroxynitrite (a short-lived oxidant species that is a potent inducer of cell death [64] and is generated in cells or tissues by the reaction of nitric oxide with superoxide radical) or hypochlorous acid (a high reactive species produced enzymatically by myel”
Salmonella enterica Serovar Typhimurium Skills To Succeed in the Host: Virulence and Regulation (2013, methodology): “Nitrate is then preferentially used as an anaerobic electron acceptor for Salmonella, even in comparison with tetrathionate (presumably because of its higher standard redox potential) (151).”
The Role of Oxidative Stress in Parkinson’s Disease (2013, background): “Peroxynitrite also induces a dose-dependent impairment in dopamine synthesis independent of dopamine oxidation or cell death [26].”
Redox Regulation of Cell Survival (2008, neutral): “) and peroxynitrite (ONOO (cid:2) ) (143).”
Reconciling the chemistry and biology of reactive oxygen species. (2008, background): “Space limitations preclude coverage here, and for information on production of nitric oxide and its antimicrobial and inflammatory actions readers are referred to other review”
First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): Their fundamental role in the entire antioxidant defence grid (2018, background): “These two radicals are believed to be the main actors in peroxynitrite-related cellular damage.(22) Besides, there are a couple of other reactive species that result from superoxide anion.”