Chemistry and biology of reactive oxygen species in signaling or stress responses
By B. Dickinson, Christopher J. Chang. Nature Chemical Biology, 2011
1,620 citations recorded by the source corpus.
Reactive oxygen species (ROS) are a family of molecules that are continuously generated, transformed and consumed in all living organisms as a consequence of aerobic life. The traditional view of these reactive oxygen metabolites is one of oxidative stress and damage that leads to decline of tissue and organ systems in aging and disease. However, emerging data show that ROS produced in certain situations can also contribute to physiology and increased fitness. This Perspective provides a focused discussion on what factors lead ROS molecules to become signal and/or stress agents, highlighting how increasing knowledge of the underlying chemistry of ROS can lead to advances in understanding their disparate contributions to biology. An important facet of this emerging area at the chemistry-biology interface is the development of new tools to study these small molecules and their reactivity in complex biological systems.
Subfields: Biochemistry, Molecular Biology, Nutrition and Dietetics
View Paper: https://www.semanticscholar.org/paper/deefad6f743a168f24f801661ef011db74f86172
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Citations in the corpus
- The interaction between ferroptosis and lipid metabolism in cancer (2020, background): “Superoxide (O2 ), hydroxyl radical (HO), hydrogen peroxide (H2O2), and lipid peroxides (ROOH) are common types of ROS in organisms.(23) ROS possess multiple roles in cancer, such as enhancing cell proliferation and survival, causing DNA damage and genetic instability, cell death and”
- Upsides and Downsides of Reactive Oxygen Species for Cancer: The Roles of Reactive Oxygen Species in Tumorigenesis, Prevention, and Therapy (2012, neutral): “Whether hydrogen peroxide (H2O2), a hydroxyl radical, or superoxide, all are constantly generated and eliminated in the biological system and are required to drive regulatory pathways (75).”