Reconciling the chemistry and biology of reactive oxygen species.

By C. Winterbourn. Nature Chemical Biology, 2008

2,243 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/79445b2d8f9c8e934845ceec635b4716f0dde3a4

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Rafael Radi
2. P. Nagy
3. Leslie B. Poole
4. M. Davies
5. C. Winterbourn
6. B. Dickinson
7. G. Shadel
8. T. Horvath

In Molecular Biology

1. Barry Halliwell
2. Rafael Radi
3. Leslie B. Poole
4. M. Murphy
5. James J. Collins
6. G. Shadel
7. C. Winterbourn
8. P. Nagy

In Physiology

1. Rafael Radi
2. G. Shadel
3. B. Dickinson
4. Christopher J. Chang
5. T. Horvath
6. Leslie B. Poole
7. M. Davies
8. D. Bailey

Citations in the corpus

• Proline Mechanisms of Stress Survival (2013, background): “, H2O2), however, is also an important physiological signaling molecule that triggers adaptive and survival responses by regulating cell death, proliferation, and apoptosis (36, 139).”
• The Role of Oxidative Stress in Neurodegenerative Diseases (2015, background): “Since PRX are abundant in eukaryotic cells, constitute approximately more than 1% of cellular proteins, and show high reactivity, PRX are responsible for the reduction of up to 90% of mitochondrial H2O2 and almost 100% of cytoplasmic H2O2 [48-51].”
• Upsides and Downsides of Reactive Oxygen Species for Cancer: The Roles of Reactive Oxygen Species in Tumorigenesis, Prevention, and Therapy (2012, neutral): “Under normal physiologic conditions, cells control reactive oxygen species (ROS) levels by balancing the generation of ROS with their elimination by a scavenging system (328).”
• T cell lipid peroxidation induces ferroptosis and prevents immunity to infection (2015, background): “Indeed, RAS–RAF–MEK signaling has been shown to be required for erastin-induced ferroptosis of tumor cells (Yagoda et al., 2007).”
• The Basics of Thiols and Cysteines in Redox Biology and Chemistry (2014, background): “Furthermore, emphasis must be placed on the kinetic pathways and rates associated with given reactions, as these considerations more than the thermodynamic driving forces tend to dominate in determining which of many competing reactions occur in the dynamic and complex environment of a living cell [”
• Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations. (2012, background): “As pointed out in a recent review [3], reactive oxygen and nitrogen species are not single entities but represent a broad range of chemically distinct reactive species with diverse biological reactivities [3,4].”