Chitin induces accumulation in tissue of innate immune cells associated with allergy

By Tiffany A. Reese, Hong-Erh Liang, A. Tager, A. Luster, N. Rooijen, D. Voehringer, R. Locksley. Nature, 2007

800 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Parasitology

View Paper: https://www.semanticscholar.org/paper/d723cd48940c41be4659fe18545f7634bb93be2e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. TA Wynn
2. A. Mantovani
3. R. Medzhitov
4. A. Sica
5. S. Gordon
6. Shizuo Akira
7. P. Murray
8. R. Locksley

In Molecular Biology

1. Shizuo Akira
2. O. Takeuchi
3. R. Medzhitov
4. A. Sica
5. S. Gordon
6. P. Murray
7. Luke Barron
8. A. Chawla

In Parasitology

1. TA Wynn
2. A. Mantovani
3. A. Sica
4. R. Locksley
5. S. V. Van Dyken
6. R. Medzhitov

Citations in the corpus

• Alternative activation of macrophages: mechanism and functions. (2010, background): “Chitin induces Th2 cell responses (Reese et al., 2007; Voehringer et al., 2006) and can be degraded by glucanases, and MRC1 contributes to chitin binding.”
• Recognition of microorganisms and activation of the immune response (2007, background): “Recently, however, one of the main parasite-associated cell-wall components, chitin, was found to induce eosinophil recruitmen”
• Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages (2013, methodology): “Images were resolved to 1.2 µm/pixel in the xy plane and 1.0 µm in the z plane. allele in the arginase1 gene, permitting identification of AAMs, as previously described (Reese et al., 2007; Wu et al., 2011).”
• Macrophages: Master Regulators of Inflammation and Fibrosis (2010, background): “Although AMCase and BRP-39 were both identified as critical mediators of IL-13-induced responses, other studies have shown that IL-4/13-induced AMCase activity inhibits chitin from promoting Th2, AAMw, and allergic responses.(130) Further study is clearly warranted to better understand the role of A”
• Exploring the full spectrum of macrophage activation (2008, background): “In addition to injury, these cells can also produce IL-4 in response to chitin, a structural biopolymer that is found in some fungi and parasite”
• A Comprehensive Look at the Possibilities of Edible Insects as Food in Europe – a Review (2014, background): “…allergen but can cause sensitization through frequent exposure [Burton & Zaccone, 2007] and is a recognition element for tissue infi ltration by innate cells implicated in allergic and helminth immunity and this process can be negatively regulated by a  vertebrate chitinase [Reese et al., 2007].”
• Macrophage plasticity and polarization: in vivo veritas. (2012, positive): “Evidence now indicates that chitin- and arginase-dependent M2 pathways play an active role in pathogenesis (75, 76).”
• Overview of the Immune Response (2003, background): “The acidic mammalian chitinase (AMC) rapidly degrades chitin, contributing importantly to host defense against chitin-expressing organisms, dramatically reducing the allergic inflammatory response these organisms induce.(93) AMC, which is expressed in epithelial cells, as well as tissue leukocytes, ”
• The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection (2010, background): “It has been shown that chitin administration recruits macrophages with the M2 phenotype to the site of administration, which are important for subsequent recruitment of eosinophil”