Exploring the full spectrum of macrophage activation

By D. Mosser, J. Edwards. Nature reviews. Immunology, 2008

8,598 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/5263e9448f84c7524bcf7c4a3f4019d9a51abc46

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Citations in the corpus

Biomaterial based modulation of macrophage polarization: A review and suggested design principles (2015, background): “Alternatively, the M2c subset is induced by IL-10 and plays a major role in tissue remodeling and suppression of inflammatory immune reactions by secreting transforming growth factor-b (TGF-b) and IL-10 [1,23].”
Aging and aging-related diseases: from molecular mechanisms to interventions and treatments (2022, background): “These cytokines induce inflammation and promote monocyte infiltration into the liver.(327) Recent studies have found that monocyte-derived KCs appear in the liver during NASH.”
Protective and pathogenic functions of macrophage subsets (2011, background): “Tumour-associated macrophages (TAMs) suppress antitumour immunity, and myeloid-derived suppressor cells (MDSCs) are linked to TAMs and may be their precursor”
A Distinct Macrophage Population Mediates Metastatic Breast Cancer Cell Extravasation, Establishment and Growth (2009, background): “They probably differentiate from monocytes precursors that are restricted to blood and seed most macrophages but it cannot be ruled out that they cross-differentiate from other resident macrophages as has been described in some immune responses [61].”
From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation (2014, background): “The authors believe that this classification also helps to illustrate how macrophages can evolve to exhibit characteristics that are shared by more than one macrophage population (181).”
Adipokines Mediate Inflammation and Insulin Resistance (2013, background): “…nitric-oxide synthase (NOS2) expression in classically activated macrophages (M1), whereas the Th2 cytokines such as IL-4 and IL-13 induce arginase-1 (ARG1) in alternatively activated macrophages (M2) (Mantovani et al., 2004; Lumeng et al., 2007a,b; Mosser and Edwards, 2008; Martinez et al., 2009).”
Macrophages in skin injury and repair. (2011, neutral): “These diseases are the result of a T-helper (Th)-2 response, which is predominated by IL-4 or IL-10 (Mosser and Edwards 2008).”
Macrophage plasticity and polarization in tissue repair and remodelling (2013, background): “M1 and M2 or M2-like polarized macrophages represent extremes of a continuum of functional states [4,5,42].”
The tumor microenvironment underlies acquired resistance to CSF1R inhibition in gliomas (2016, methodology): “We computationally interrogated a spectrum model of macrophage activation, defined by gene sets that are altered in response to different stimuli, including interferon-g (IFN-g), IL4, TNFa, transforming growth factor–b1 (TGFb1), IL1b, and two Toll-like receptor (TLR) agonists specific for TLR2 [macr”