Macrophage plasticity and polarization: in vivo veritas.

By A. Sica, A. Mantovani. Journal of Clinical Investigation, 2012

5,792 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/c4c11261e52e40108d47daf417aba08b4f3e1835

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

1. A. Mantovani
2. A. Sica
3. P. Allavena
4. P. Italiani
5. Subhra K. Biswas
6. Ava J Boutilier
7. C. Varol
8. M. Locati

Citations in the corpus

• Macrophage Polarization States in the Tumor Microenvironment (2021, background): “Current literature supports the theory that most TAMs originate from either tissueresident embryonic macrophages or macrophages derived from circulating monocytes that originate in the bone marrow [87].”
• Sequential delivery of immunomodulatory cytokines to facilitate the M1-to-M2 transition of macrophages and enhance vascularization of bone scaffolds (2014, unknown): “However, whether the macrophages themselves change phenotypes or a new wave of arriving macrophages takes on a new phenotype is more controversial [42].”
• Biomaterial based modulation of macrophage polarization: A review and suggested design principles (2015, unknown): “M1 IFN-g, LPS IL - 1b, 6, 12, 15, 18, 23; TNF-a; CCL - 15, 20; CXCL - 9, 10, 11, 13 h CD - 80, 86; h MHC II; i MRC1 Pro-inflammatory, killing of intracellular pathogens by iron restriction, phagocytosis [14,16,18]”
• NF-κB signaling in inflammation (2017, unknown): “30,31 In contrast, M2 macrophages produce anti-inflammatory cytokines, such as IL-10 and IL-13, and are important for resolution of inflammation and mediating wound healing.”
• Immune cell infiltration as an indicator of the immune microenvironment of pancreatic cancer (2013, background): “Macrophages are heterogeneous and can be divided into classically activated macrophages (alternatively M1 macrophages, M1) that are activated mainly by Th1 cytokines and alternatively activated macrophages (alternatively M2 macrophages, M2) that are activated mainly by Th2 cytokines (Mantovani et al”
• Macrophage plasticity, polarization, and function in health and disease (2018, background): “Therefore, it is clear that divergent iron management seems to be an important metabolic signature in polarized macrophages (Biswas & Mantovani, 2012; Biswas et al., 2012).”
• Microglial M1/M2 polarization and metabolic states (2016, background): “M2 macrophages play a role in allergy response, parasite clearance, inflammatory dampening, tissue remodelling, angiogenesis, immunoregulation and tumour promotion (Sica and Mantovani, 2012).”
• Metabolic dysfunction drives a mechanistically distinct proinflammatory phenotype in adipose tissue macrophages. (2014, background): “Concordant with our findings, previous studies suggested the presence of mixed macrophage phenotypes in obese human subjects and mice (Sica and Mantovani, 2012; Zeyda et al., 2007).”
• Neuroinflammation and M2 microglia: the good, the bad, and the inflamed (2014, background): “Both IL-4 and the closely related cytokine IL-13 signal through IL-4Rα to induce a host of downstream processes that lead to potent anti-inflammatory functions, such as Arg1 upregulation, inhibition of NF-κB isoforms, and production of scavenger receptors for phagocytosis [19,47,48].”
• Inflammation and Immunity in the Pathogenesis of Pulmonary Arterial Hypertension (2014, unknown): “A useful oversimplification of the athymic/immune dysregulation model is that after vascular injury in animals with a healthy immune systems, normal Treg activity skews macrophage responses to promote injury resolution, but that without this Treg activity (as observed in T-cell deficient athymic rat”
• Tumor associated macrophages and neutrophils in cancer. (2013, background): “Roles of macrophages in cancer Plasticity is a well-known characteristic of macrophages and consists on their ability to integrate distinct signals from the microenvironment and to acquire distinct phenotypes (Sica and Mantovani 2012).”
• Tumor-associated macrophages: from mechanisms to therapy (2014, background): “References to these polarizing agents can be found in (De Palma and Lewis, 2013; Sica and Mantovani, 2012). above strongly support targeting the destruction or redifferentiation of macrophages as an important part of combinatorial therapies in human cancer patients.”