Recognition of microorganisms and activation of the immune response

By R. Medzhitov. Nature, 2007

2,945 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/f657ff636f9dad263bf2b8310b2d605830aa27fe

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In Immunology

Citations in the corpus

NLRP3 Inflammasome and the IL-1 Pathway in Atherosclerosis. (2018, background): “Besides of cellular components, the innate immune system also comprises humoral factors including acute phase proteins and complement factors, which are classically considered as opsonins and lytic agents.(119,120) However, factors of the complement system have also been shown to upregulate IL-1β ex”
CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer (2009, background): “We therefore tested whether fibrillar β-amyloid peptide (1-42) (Aβ1-42) could activate TLR4-TLR6 signaling via CD36.”
The Structural Biology of Toll-Like Receptors (2011, background): “Innate immune receptors, also known as pattern recognition receptors (PRRs), have been identified in the serum, on the cell surface, in endosomes, and in the cytoplasm (Medzhitov, 2007).”
INTERLEUKIN-4- AND INTERLEUKIN-13-MEDIATED ALTERNATIVELY ACTIVATED MACROPHAGES: ROLES IN HOMEOSTASIS AND DISEASE (2013, positive): “In this respect, the characterization of several germ line–encoded pattern-recognition receptors (PRRs) and subsequent intracellular signaling events induced upon PRR ligation has been instrumental in providing molecular links between the initial sensing of foreign material and the distinct cellular”
The NALP3/NLRP3 Inflammasome Instigates Obesity-Induced Autoinflammation and Insulin Resistance (2011, background): “Thus, while the specific release of proinflammatory cytokines by macrophages during infection is a critical mechanism for a protective immune respons”
Overview of the Immune Response (2003, background): “The TLRs appear largely to recognize pathogen-associated molecular patterns.(83) These include LPS from gram-negative bacteria, peptidoglycan, lipoteichoic acid, lipoarabinomannan, bacterial flagellar proteins, viral double-stranded RNA, and unmethylated DNA with CpG motifs characteristic of microbi”
Wheat amylase trypsin inhibitors drive intestinal inflammation via activation of toll-like receptor 4 (2012, background): “…are primarily macrophages, monocytes, DCs, and polymorphonuclear leukocytes that by means of their pattern-recognition receptors, such as TLRs, induce the release of proinflammatory cytokines and chemokines, resulting in recruitment and activation of additional inflammatory cells (Medzhitov, 2007).”
A Nurr1/CoREST transrepression pathway attenuates neurotoxic inflammation in activated microglia and astrocytes (2009, neutral): “The TLRs play essential roles in innate immune responses to microbial pathogens based on their ability to recognize pathogen-associated molecular patterns (Akira et al., 2006; Medzhitov, 2007).”