Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages

By Ari B. Molofsky, J. Nussbaum, Hong-Erh Liang, S. V. Van Dyken, Laurence E. Cheng, Alexander Mohapatra, A. Chawla, R. Locksley. Journal of Experimental Medicine, 2013

846 citations recorded by the source corpus.

Innate lymphoid type 2 cells maintain eosinophils and alternatively activated macrophages in visceral fat via the production of IL-5 and IL-13.

Subfields: Immunology, Surgery

View Paper: https://www.semanticscholar.org/paper/1fb85c35cd5d213bc3768655615ae1fea8dc21bd

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. D. Artis
2. C. Garlanda
3. A. Mantovani
4. H. Spits
5. R. Locksley
6. B. Spiegelman
7. A. Chawla
8. Andrew N. J. McKenzie

In Surgery

1. D. Artis
2. D. Umetsu
3. R. DeKruyff
4. Yajie Chang
5. Hye Young Kim
6. Sanhong Yu
7. Andrew N. J. McKenzie
8. H. Spits

Citations in the corpus

• THE INTERLEUKIN-1 FAMILY: BACK TO THE FUTURE (2013, positive): “IL-33 is also involved in inducing ILC2-dependent in- 1008 Immunity 39, December 12, 2013 ª2013 Elsevier Inc. creases in eosinophils and M2 polarized macrophages of visceral adipose tissue, which are implicated in metabolic homeostasis (Molofsky et al., 2013).”
• Activated Type 2 Innate Lymphoid Cells regulate Beige Fat Biogenesis (2014, positive): “In addition to their functions in immunity at mucosal sites, ILC2s have been identified in epididymal WAT (eWAT) of mice, where they sustain eosinophils and alternatively activated macrophages to promote glucose homeostasis (Molofsky et al., 2013).”
• Innate Lymphoid Cells: 10 Years On. (2018, positive): “Here, they produce IL-5 to sustain eosinophils, and IL-13 to polarize M2 macrophages and regulate adiposity and insulin resistance (Brestoff et al., 2015; Molofsky et al., 2013) (Figure 3A).”
• Innate Lymphoid Cells: a new paradigm in immunology (2015, background): “This activity ofmacrophages is dependent on IL-4 produced by eosinophils, as well as on IL-5 and IL-13 produced by ILC2s, replicating the recruitment and activation process induced by ILC2s in VAT.”
• Innate lymphoid cells and asthma. (2014, positive): “Similar interactions between ILC2s and eosinophils occur in visceral adipose tissue, where ILC2s promote the accumulation of eosinophils and maintain alternatively activated macrophages.(53) In the skin of mice, ILC2s have been shown to be abundant and require IL-7 for survival.”