Phagocytosis of microbes: complexity in action.

By D. Underhill, A. Ozinsky. Annual Review of Immunology, 2002

1,144 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/d669b63c5ab91a9a652a42b4d3d68423fba9759d

How researchers see this paper

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In Immunology

1. Shizuo Akira
2. S. Ghosh
3. A. West
4. G. Shadel
5. A. Sher
6. G. Trinchieri
7. D. Underhill
8. Randi M. Simmons

Citations in the corpus

• Rhizobacteria-induced systemic resistance (2009, background): “Then, the LPS, bound to the LPS-binding protein, is perceived by a complex that consists of the Toll-like receptor TLR4, the membrane receptor CD14, and an extracellular accessory protein MD-2 (Underhill and Ozinsky, 2002).”
• Mammalian Rho GTPases: new insights into their functions from in vivo studies (2008, background): “Studies using dominant-negative Rho GTPases have indicated that different Rho GTPases contribute to phagocytosis depending on the receptor: CDC42 and Rac are required for FcR-mediated uptake and apoptotic cell phagocytosis, whereas Rho is required for complement-mediated phagocytosi”
• Cooperation of Toll-like receptor signals in innate immune defence (2007, background): “Receptors that recognize mannans and β-glucans have been shown to have an important role in the recognition and phagocytosis of zymosan particle”
• Cell Biology of Cnidarian-Dinoflagellate Symbiosis (2012, background): “There are many excellent reviews of host-microbe signaling that cover these events in great detail (173, 233, 377).”
• An Essential Role for Talin during αMβ2-mediated Phagocytosis (2007, background): “Numerous phagocytic receptors exist that can bind their target directly or indirectly through opsonins (Underhill and Ozinsky, 2002).”
• Complement System Part I – Molecular Mechanisms of Activation and Regulation (2015, background): “CR3 and to lesser extent CR4 are essential for phagocytosis of C3 fragments, opsonized immune complexes, and pathogens (304).”
• Mitochondria in innate immune responses (2011, background): “Phagocytosis is associated with the production of ROS via the respiratory burst , a necessary effector response for the destruction of intracellular microorganism”
• Collaborative Induction of Inflammatory Responses by Dectin-1 and Toll-like Receptor 2 (2003, background): “The innate immune system uses a wide variety of microbial recognition receptors including Toll-like receptors (TLRs), * lectins, scavenger receptors, and integrins to identify potential pathogens (1).”
• Engineered nanoparticles interacting with cells: size matters (2014, background): “Red blood cells (RBCs) lack a cell nucleus, most organelles and, most importantly, the endocytic machinery [74].”
• Innate Immune Pattern Recognition: A Cell Biological Perspective (2015, neutral): “Additionally, Dectin-1 activates PLCγ2, which is a regulator of phagocytosis and may contribute to the Dectin-1-mediated phagocytic process (130, 138, 139).”
• Phosphoinositides: tiny lipids with giant impact on cell regulation. (2013, background): “Particles or cells to be phagocytosed initially attach to the cell surface, mostly via Fc Rs or CR3 complement receptors (1592).”