Complement System Part I – Molecular Mechanisms of Activation and Regulation
By N. Merle, S. Church, V. Frémeaux-Bacchi, L. Roumenina. Frontiers in Immunology, 2015
1,457 citations recorded by the source corpus.
Complement is a complex innate immune surveillance system, playing a key role in defense against pathogens and in host homeostasis. The complement system is initiated by conformational changes in recognition molecular complexes upon sensing danger signals. The subsequent cascade of enzymatic reactions is tightly regulated to assure that complement is activated only at specific locations requiring defense against pathogens, thus avoiding host tissue damage. Here, we discuss the recent advances describing the molecular and structural basis of activation and regulation of the complement pathways and their implication on physiology and pathology. This article will review the mechanisms of activation of alternative, classical, and lectin pathways, the formation of C3 and C5 convertases, the action of anaphylatoxins, and the membrane-attack-complex. We will also discuss the importance of structure–function relationships using the example of atypical hemolytic uremic syndrome. Lastly, we will discuss the development and benefits of therapies using complement inhibitors.
Subfields: Immunology, Nephrology, Physiology
View Paper: https://www.semanticscholar.org/paper/15d02f0b44fbad4fba486f157b650651b2874347
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- Jiang-Hui Wang
- N. Merle
- J. Ries
- Dominic J. Gessler
- Rémi Noé
- V. Frémeaux-Bacchi
- Wei Zhan
- L. Roumenina
Citations in the corpus
- CipA mediates complement resistance of Acinetobacter baumannii by formation of a factor I-dependent quadripartite assemblage (2022, background): “Frontiers in Immunology 02 and C4b (12, 13).”
- Adeno-associated virus as a delivery vector for gene therapy of human diseases (2024, background): “409 The mechanism of complement activation during rAAV infusion is yet to be elucidated.”
- Complement System Part II: Role in Immunity (2015, background): “Detailed description of the mechanisms of activation and regulation of the complement system are described in “Complement system part I – molecular mechanisms of activation and regulation” (1), from the same research topic of Frontiers in Immunology.”