Circulating Insulin-Like Growth Factor I Mediates Exercise-Induced Increases in the Number of New Neurons in the Adult Hippocampus

By J. Trejo, E. Carro, I. Torres-Alemán. Journal of Neuroscience, 2001

1,053 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Endocrinology, Diabetes and Metabolism

View Paper: https://www.semanticscholar.org/paper/d64efe7da152af86f371ab39bfe9c42109cb55c9

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Citations in the corpus

Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood (2006, background): “1l ), a growth factor known to be associated with neurogenesi”
Central effects of stress hormones in health and disease: Understanding the protective and damaging effects of stress and stress mediators. (2008, background): “There are many hormonal, neurochemical and behavioral modulators of neurogenesis and cell survival in the dentate gyrus including estradiol, insulin-like growth factor-1, antidepressants, voluntary exercise and hippocampal-dependent learning (Aberg et al., 2000; Trejo et al., 2001; Czeh et al., 2001”
Modification of hippocampal circuitry by adult neurogenesis (2012, background): “Two factors identified from these studies are insulin-like growth factor-1 (IGF-1) and vascular endothelial growth factor (VEGF), both of which were shown to be necessary in mediating the exercise-induced increase of neurogenesis (Trejo et al., 2001; Fabel et al., 2003).”
Exercise, cognition, and the aging brain. (2006, background): “Circulating levels and brain uptake levels of insulin-like growth factor -1 (IGF-1) are also increased with exercise (8, 38 ).”
Exercise and the brain: something to chew on (2009, background): “Blockade of peripheral VEGF and IGF-1 inhibited the increase in neurogenesis observed with running [76,79].”
Adult neurogenesis and cellular brain repair with neural progenitors, precursors and stem cells (2006, background): “2000), suggesting that IGF-I at least partially mediates the effects of exercise on neurogenesis (Trejo et al. 2001).”
The effects of exercise and stress on the survival and maturation of adult-generated granule cells (2009, neutral): “First, in several previous studies, including nearly all studies in mice, BrdU was injected over a period of 7–12 days (van Praag et al., 1999a,b; Trejo et al., 2001; Brandt et al., 2003; Farmer et al., 2004).”
Neurogenesis and Exercise: Past and Future Directions (2008, background): “Enhancement of hippocampal neurogenesis by running is a robust phenomenon (Trejo et al. 2001; Fabel et al. 2003; Kitamura et al. 2003; Overstreet et al. 2004; van der Borght et al. 2007; van Praag et al. 2007).”
Environmental enrichment and voluntary exercise massively increase neurogenesis in the adult hippocampus via dissociable pathways (2006, background): “In summary, certain trophic factors regulated by VEx (IGF-1 and FGF-2) might be more instrumental in the induction of cell proliferation, especially because blocking IGF-1 disrupts exercise-induced neurogenesis (Trejo et al., 2001).”
The Effects of Acute Exercise on Mood, Cognition, Neurophysiology, and Neurochemical Pathways: A Review (2016, background): “One study in rodents strongly supports the hypothesis that IGF-1 is involved in acute exercise-induced increases in hippocampal functioning [184].”
The many faces of insulin-like peptide signalling in the brain (2012, background): “The very low expression of IGF1 mRNA and the wide expression of IGF receptors in the adult mammalian brain suggests that peripherally produced IGF1 also has a role in the adult brai”
Glucocorticoids, depression, and mood disorders: structural remodeling in the brain. (2005, background): “There are many hormonal, neurochemical, and behavioral modulators of neurogenesis and cell survival in the dentate gyrus [12,14-17].”
Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male Sprague-Dawley rats in vivo. (2004, result): “These results are in accordance with work by other laboratories in rats (Carro et al., 2000; Trejo et al., 2001), and similar to our previous findings in mice (van Praag et al.”