Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male Sprague-Dawley rats in vivo.

By J. Farmer, Xinyu Zhao, H. van Praag, K. Wodtke, Fred H. Gage, B. Christie. Neuroscience, 2004

844 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience

View Paper: https://www.semanticscholar.org/paper/6ac407c0b8ae82403c8faa897909d45c7995954b

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In Cellular and Molecular Neuroscience

In Developmental Neuroscience

Citations in the corpus

The effects of exercise and stress on the survival and maturation of adult-generated granule cells (2009, positive): “Several previous running studies have included a “survival” measure, determining the number of cells remaining in runners and controls several weeks after BrdU injections (Brandt et al., 2003; Farmer et al., 2004; Holmes et al., 2004; Trejo et al., 2001; van Praag et al., 1999a; van Praag et al., 19”
Stress and adult neurogenesis (2006, background): “genesis (van Praag et al., 1999a,b; Fabel et al., 2003; Farmer et al., 2004).”
Exercise Enhances Learning and Hippocampal Neurogenesis in Aged Mice (2005, background): “In addition, exercise enhances hippocampal neurogenesis (van Praag et al., 1999a,b; Fabel et al., 2003; Farmer et al., 2004), a process that may contribute to cognition (Lemaire et al.”
Neurogenesis and Exercise: Past and Future Directions (2008, methodology): “anesthetized rats that have been housed with a running wheel (Farmer et al. 2004) or given forced treadmill”
Aerobic Fitness is Associated With Hippocampal Volume in Elderly Humans (2009, positive): “, 2007), enhances long-term potentiation and induces synaptic plasticity (Farmer et al., 2004; Christie et al., 2008), and enhances hippocampal-dependent learning and memory processes as assessed by Morris water maze and radial arm maze performance (Fordyce and Wehner, 1993; Anderson et al.”
Harnessing neuroplasticity for clinical applications (2011, positive): “Aerobic exercise is associated with increased neurogenesis and angiogenesis, as well as the production of neurotrophic molecules such as brain-derived neurotrophic factor and other growth factors involved in neuroprotection and the promotion of cell survival, neurite outgrowth and synaptic plasticit”
Social isolation prevents exercise‐induced proliferation of hippocampal progenitor cells in female rats (2009, background): “During the last decade, many studies have shown that exercise increases birth of new cells in the dentate gyrus (van Praag et al., 1999; Trejo et al., 2001; Kim et al., 2002; Ra et al., 2002; Fabel et al., 2003; Rhodes et al., 2003; Farmer et al., 2004; Bjornebekk et al., 2005; Naylor et al., 2005; ”
A critical period for enhanced synaptic plasticity in newly generated neurons of the adult brain. (2007, positive): “Previous studies using field recordings from a heterogeneous neuronal population, consisting of mature DGCs and newborn DGCs of mixed ages, provided indirect evidence suggesting that new neurons exhibit an enhanced synaptic plasticity ( Farmer et al., 2004; Snyder et al., 2001; van Praag et al., 19”
The Effects of Acute Exercise on Mood, Cognition, Neurophysiology, and Neurochemical Pathways: A Review (2016, background): “BDNF is one of the main regulators of neurogenesis and is also involved in enhancing neuronal differentiation and survival, synaptic transmission, and LTP.”
Distinct Morphological Stages of Dentate Granule Neuron Maturation in the Adult Mouse Hippocampus (2006, background): “…in rodents can lead to an upregulation of genes related to neuronal activity and synaptic plasticity (Tong et al., 2001; Molteni et al., 2002; Farmer et al., 2004), which could be responsible for the high spine motility in running mice at 21 dpi, when the peak of spine growth occurs in new…”
Exercise, cognition, and the aging brain. (2006, background): “(17) also reported that brain-derived neurotrophic factor (BDNF) mRNA levels were elevated in the dentate gyrus of running animals, but not in other areas of the hippocampus, and that this elevation may be related to enhanced neurogenesis and learning in exercising animals.”