Glucocorticoids, depression, and mood disorders: structural remodeling in the brain.

By Bruce S. McEwen. Metabolism: Clinical and Experimental, 2005

719 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Biological Psychiatry, Social Psychology

View Paper: https://www.semanticscholar.org/paper/d6f8075a4dabd9fbb7a972bedf4d898918ec0f62

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Citations in the corpus

Behavior Problems After Early Life Stress: Contributions of the Hippocampus and Amygdala (2014, background): “activity may lead to a loss of neurons (70,74).”
Adult hippocampal neurogenesis in depression (2007, background): “Preclinical studies show that volumetric changes result from reduced dendritic complexity and not from ablation of hippocampal neurogenesi”
Evolution and ontogeny of stress response to social challenges in the human child (2006, background): “Cortisol regulation allows the body to respond to changing environmental conditions by preparing for, and recovering from, speciWc short-term demands (Korte, Koolhaas, WingWeld, & McEwen, 2005; Mason, 1971; Munck, Guyre, & Holbrook, 1984).”
Brain-Derived Neurotrophic Factor and Neuropsychiatric Disorders (2012, background): “…role of BDNF in LTP facilitation, it is not surprising that experimental loss of BDNF signaling through genetic models or pharmacological manipulation leads to impaired LTP (Patterson et al., 1996; Monteggia et al., 2004) and decreased learning and memory in behavioral paradigms (Lu et al., 2008).”
Reconsidering Anhedonia in Depression: Lessons from Translational Neuroscience (2010, background): “…glucocorticoid signaling (Holsboer, 2000), precipitate neuronal degeneration in the hippocampus (Sapolsky, 2000) and medial prefrontal cortex (McEwen, 2005; Radley et al., 2006), decrease the availability of brainderived neurotrophic factor (BDNF) (Duman, 2009), and increase levels of…”
Towards a glutamate hypothesis of depression (2011, background): “The effects of stress on structural remodeling in the brain have been investigated by a number of studies (for a review see: Gorman and Docherty, 2010; Holmes and Wellman, 2009; McEwen, 2005; Musazzi et al., 2011; Pittenger and Duman, 2008; Shansky and Morrison, 2009).”
Allostatic load biomarkers of chronic stress and impact on health and cognition. (2010, background): “Furthermore, theoretical literature linking AL composites to psychopathologies like mood disorders (Kapczinski et al., 2008; McEwen, 2003c, 2004, 2005), anxiety disorders (McEwen, 2002; Schulkin et al., 1994, 1998), and substance-abuse (Koob, 2003; Koob et al., 2004; Koob and Le Moal, 2001;…”
Prospective reports of chronic life stress predict decreased grey matter volume in the hippocampus (2007, background): “A secondary finding of the present study was that chronic perceived stress predicted decreased grey matter volume in the right orbitofrontal area of the prefrontal cortex, an area that supports a range of emotional and cognitive processes and that participates in the negative feedback regulation of ”
Structural Plasticity and Hippocampal Function (2010, background): “These may include other types of structural change (reviewed in McEwen 2005), a possibility that is supported by the demonstration that hippocampal spine synapse loss occurs in animal models of depression (Hajszan et al. 2009).”