The p38 signal transduction pathway: activation and function.

By Koh Ono, Jiahuai Han. Cellular Signalling, 2000

1,684 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/d28e8359e8b00d62a6ba3ef73993aa69189be628

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Citations in the corpus

p38 and JNK MAPK pathways control the balance of apoptosis and autophagy in response to chemotherapeutic agents. (2014, background): “There are four genes that encode p38 MAPK: a, b, c and d, which differ in their tissue expression patterns and affinity for upstream activators and downstream effectors [15].”
Flavonoids as anti-inflammatory agents: implications in cancer and cardiovascular disease (2009, background): “P38-MAPK positively regulates a number of cytokine genes in vitro including TNF-a, IL-6 and iNOS [104, 105].”
p38 MAPK Regulates Expression of Immune Response Genes and Contributes to Longevity in C. elegans (2006, background): “elegans p38 MAPK signaling have similarities with mammalian p38 MAPK signaling, which controls production of secreted antimicrobials and inflammatory cytokines in response to lipopolysaccharide [38].”
p38MAPK is a novel DNA damage response‐independent regulator of the senescence‐associated secretory phenotype (2011, background): “…the SASP had not been explored. p38MAPK is known to upregulate specific cytokines such as IL-6, IL-8, and TNFa in some biological contexts (Ono and Han, 2000; Zhang et al, 2007), but the upregulation is generally an acute response, whereas the SASP is chronic and includes 440 secreted…”
The role of glutathione-S-transferase in anti-cancer drug resistance (2003, background): “Many anticancer agents induce apoptosis via activation of the MAP kinase pathway, specifically via JNK and p38 (Davis, 2000; Ono and Han, 2000).”
Adiponectin, a Therapeutic Target for Obesity, Diabetes, and Endothelial Dysfunction (2017, background): “p38 MAPK, which belongs to the group of stress-activated kinases, has been connected with a large number of cellular processes, including cell growth and differentiation, apoptosis, and inflammation; in addition, it gets activated in response to a numerous extracellular stimuli [62].”
The importance of glutathione in human disease. (2003, background): “Many anticancer agents induce apoptosis via activation of MAP kinase pathways, in particular those involving JNK and p38 [50,51].”
ERK and p38 MAPK-Activated Protein Kinases: a Family of Protein Kinases with Diverse Biological Functions (2004, neutral): “tion factors, and cell surface receptors (143).”
Regulation of C2C12 myogenic terminal differentiation by MKK3/p38α pathway (2003, background): “The stress-activated protein kinases c-Jun NH2-terminal kinase (JNK) and p38 (20, 26) are part of the mitogen-activated protein kinase (MAPK) family, which includes extracellular signal-regulated kinase (ERK)1 and ERK2.”
Signal integration by JNK and p38 MAPK pathways in cancer development (2009, background): “Most of the published literature on p38 MAPKs refers to p38&alpha”
Role of Glutathione in Cancer Progression and Chemoresistance (2013, background): “Many anticancer agents induce apoptosis via activation of MAP kinases, in particular JNK and p38 [75, 76].”