Role of Glutathione in Cancer Progression and Chemoresistance
By N. Traverso, R. Ricciarelli, M. Nitti, B. Marengo, A. Furfaro, M. Pronzato, U. Marinari, C. Domenicotti. Oxidative Medicine and Cellular Longevity, 2013
1,144 citations recorded by the source corpus.
Glutathione (GSH) plays an important role in a multitude of cellular processes, including cell differentiation, proliferation, and apoptosis, and disturbances in GSH homeostasis are involved in the etiology and progression of many human diseases including cancer. While GSH deficiency, or a decrease in the GSH/glutathione disulphide (GSSG) ratio, leads to an increased susceptibility to oxidative stress implicated in the progression of cancer, elevated GSH levels increase the antioxidant capacity and the resistance to oxidative stress as observed in many cancer cells. The present review highlights the role of GSH and related cytoprotective effects in the susceptibility to carcinogenesis and in the sensitivity of tumors to the cytotoxic effects of anticancer agents.
Subfields: Biochemistry, Molecular Biology, Rheumatology
View Paper: https://www.semanticscholar.org/paper/e603041defc99179bde16365ff9338e794cbfe12
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In Biochemistry
In Molecular Biology
- Tal Hirschhorn
- Shanmugasundaram Ganapathy-Kanniappan
- M. C. Simon
- Brent R. Stockwell
- Ankita Bansal
- J. Geschwind
- Scott J. Dixon
- R. Kang
Citations in the corpus
- Drug resistance and combating drug resistance in cancer (2019, background): “efflux[32] and glutathione (GSH)/glutathione S-transferase system[33], working to reduce cellular drug accumulation or detoxify drug treated cancer cells respectively.”
- Role of Glutathione in Cancer: From Mechanisms to Therapies (2020, background): “It is well-known that shifts in GSH metabolism often accompany tumor development, potentially as a way for the cancer cells to mitigate the impact of increased oxidative stress that results from their extraordinary metabolic rates [59].”
- Glutathione metabolism in cancer progression and treatment resistance (2018, background): “This pathway, also known as the γ glutamyl cycle (Traverso et al., 2013), is an alternative to the de novo biosynthetic pathway and plays an important role in maintaining intracellular GSH and cysteine (Zhang and Forman, 2009).”
- The Development of the Concept of Ferroptosis (2018, positive): “of antioxidant enzymes [213], and glutathione and thioredoxin antioxidant systems are commonly activated in cancers [214,215].”
- Tumor glycolysis as a target for cancer therapy: progress and prospects (2013, background): “GSH plays a pivotal role in protecting cancer cells against antineoplastic agents by maintaining the redox status as well as by counteracting some of the effects from chemotherapeutic agents (reviewed [33,34]).”