Signal integration by JNK and p38 MAPK pathways in cancer development

By E. Wagner, A. Nebreda. Nature Reviews. Cancer, 2009

2,607 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/fa19eaa3e5805d9f06ad3e5944656ea70c066552

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In Cancer Research

Walter Kolch

In Molecular Biology

In Pathology and Forensic Medicine

Citations in the corpus

Cell Death Pathways in Photodynamic Therapy of Cancer (2011, background): “They concluded that both JNK1 and p38 MAPK pathways played an important role in cellular resistance to PDT-induced apoptosis with hypericin.”
Understanding MAPK Signaling Pathways in Apoptosis (2020, background): “The stress-activated JNKs and p38 MAPKs play key roles in balancing cell survival and death in response to both extracellular and intracellular stresses (reviewed in [12]).”
Targeting MAPK Signaling in Cancer: Mechanisms of Drug Resistance and Sensitivity (2020, background): “The anti-estrogen tamoxifen is a mainstay in the treatment of hormone sensitive breast cancers, and p38 pathway activation correlates with tamoxifen resistance and poor prognosis [117].”
Controlling gene expression in response to stress (2011, background): “For example, the SAPKs in mammals are the p38 mitogen-activated protein kinase (MAPK) family (which contains four isoforms, MAPK11–14); these signalling pathways are activated by a variety of environmental (physical and chemical) stresses, such as heat shock, ultraviolet light, gamma rays, anisomyci”
ERK/MAPK signalling pathway and tumorigenesis (2020, background): “Excessive activation of upstream proteins and kinases in the ERK pathway has been shown to induce various diseases, including cancer, inflammation, developmental disorders and neurological disorders (18-22).”
The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocation. (2011, background): “Other pathologies in which JNKs are involved include diabetes [23], in ﬂ ammation [41], and several cancer types [42].”
NF-κB in biology and targeted therapy: new insights and translational implications (2024, background): “114 Cellular responses exhibit variability based on the nature of the stimulus, the extent of JNK activation, and the duration of the response.”
Maturation and integration of adult born hippocampal neurons: signal convergence onto small Rho GTPases (2013, background): “For example, pathways such as mitogen-activated protein (MAP) kinase and CREB are common targets of many upstream regulators and have been hypothesized to act as signal integrators for certain cellular processes (Wagner and Nebreda, 2009; Merz et al., 2011).”