The importance of glutathione in human disease.

By D. Townsend, K. Tew, H. Tapiero. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2003

1,861 citations recorded by the source corpus.

Subfields: Biochemistry, Molecular Biology, Rheumatology

View Paper: https://www.semanticscholar.org/paper/ae430d75e3f7f50b381c416fe68e9de42ff365e7

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. Guoyao Wu
2. V. Lushchak
3. A. Fardet

In Molecular Biology

1. Guoyao Wu
2. V. Lushchak
3. W. E. Hennink
4. A. Fardet
5. H. Sies

In Rheumatology

1. Guoyao Wu
2. A. Fardet

Citations in the corpus

• New hypotheses for the health-protective mechanisms of whole-grain cereals: what is beyond fibre? (2010, background): “Health and diseases((650)); source of cysteine((651)); oral cancer, anti-carcinogen, antioxidant effect, binding with cellular mutagens and GSH transferase activity((110)); detoxification of toxic electrolytic metabolites, xenobiotics and reactive oxygen intermediates((652)); cellular immune functio”
• Role of Glutathione in Cancer Progression and Chemoresistance (2013, background): “The reversible thiolation of proteins is known to regulate several metabolic processes including enzyme activity, transport activity, signal transduction and gene expression through redox-sensitive nuclear transcription factors such as AP-1, NF-kappaB (NFkB) and p53 [21, 23].”
• Glutathione dysregulation and the etiology and progression of human diseases (2009, background): “…surprising that alterations in GSH homeostasis have been implicated in the etiology and/or progression of a number of human diseases (Cerutti, 1985; Townsend et al., 2003; Liu et al., 2004; Ballatori et al., 2005; Estrela et al., 2006; Franco et al., 2007; Kinnula et al., 2007; Reynolds et al.,…”
• Glutathione Homeostasis and Functions: Potential Targets for Medical Interventions (2012, background): “For example, in many solid tumors enhanced resistance to drugs is associated with the increased activity of GSTs that detoxify xenobiotics [27, 146].”
• Glutathione in Cancer Biology and Therapy (2006, neutral): “acid (γ -Glu-aa) transporter; (3) dipeptidases; (4) Cyst(e)ine transporters; (5) γ -Glu-cyclotransferase; (6) 5-oxoprolinase; (7) GCS; (8) GSHS; (9) GPx; (10) GR; (11) transhydrogenases; (12) GSTs.”
• Glutathione metabolism and its implications for health. (2004, methodology): “Glutathione can be transported out of cells via a carrier-dependent facilitated mechanism (2).”
• Reduction-sensitive polymers and bioconjugates for biomedical applications. (2009, background): “Thiol–disulfide exchange reactions, which are rapid and readily reversible, play an important role in maintaining proper biological functions of living cells, including stabilization of protein structures, enzymatic activity, and redox cycles [6–8].”
• Redox status expressed as GSH:GSSG ratio as a marker for oxidative stress in paediatric tumour patients. (2012, positive): “The ratio of reduced to oxidised glutathione within cells is often used as a marker of cellular toxicity (9-12).”