TOR, a central controller of cell growth.

By T. Schmelzle, Michael N. Hall. Cell, 2000

2,036 citations recorded by the source corpus.

Subfields: Ecology, Evolution, Behavior and Systematics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/d0edef6fc82c45cb86e9692f6ccb04cc76b6dd3b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Ecology, Evolution, Behavior and Systematics

1. Nahum Sonenberg
2. Kim Lewis
3. J. Blenis
4. N. Hay
5. D. E. Levin
6. E. Jacinto
7. Steven P. Gygi
8. Bryan A. Ballif

In Molecular Biology

1. David M. Sabatini
2. Michael N. Hall
3. K. Guan
4. M. Laplante
5. J. Blenis
6. Nahum Sonenberg
7. N. Hay
8. R. Loewith

Citations in the corpus

• Glutamine Uptake and Metabolism Are Coordinately Regulated by ERK/MAPK During T Lymphocyte Activation (2010, background): “and the target of rapamycin (TOR, known as mTOR in mammalian cells) kinase (44).”
• Glutaminolysis activates Rag-mTORC1 signaling. (2012, background): “mTORC1 activates cell growth (Fingar et al., 2002; Schmelzle and Hall, 2000) and inhibits autophagy (Meijer and Codogno, 2009).”
• mTOR Is Essential for Growth and Proliferation in Early Mouse Embryos and Embryonic Stem Cells (2004, background): “Mammalian TOR (mTOR; also known as FRAP [FKBP12rapamycin-associated protein], RAFT [rapamycin and FKBP12 target], and RAPT [rapamycin target]) belongs to the phosphoinositide kinase-related kinase (PIKK) family (21, 48).”
• mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. (2005, positive): “The mammalian target of rapamycin, mTOR, has emerged as a critical nutritional and cellular energy checkpoint sensor and regulator of cell growth in mammalian cells (Gingras et al., 2001; Richardson et al., 2004; Schmelzle and Hall, 2000).”
• Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. (2002, background): “1995), is a large (289kD), evolutionarily conserved member of the phosphatidylinositol kinase (PIK)-related kinase family in which a lipid kinase homology domain functions as a serine/ threonine kinase to regulate protein translation, cell cycle progression, and cellular proliferation (Schmelzle and”
• Regulation of Dendritic Morphogenesis by Ras–PI3K–Akt–mTOR and Ras–MAPK Signaling Pathways (2005, background): “p70S6Ks requires hierarchical phosphorylation by mTOR and MAPK for optimal activation (Schmelzle and Hall, 2000).”
• Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy (2004, background): “mTOR normally regulates translation in response to nutrients and growth factors by phosphorylating key components of the protein synthesis machinery, including the above mentioned ribosomal protein S6 kinase, p70 S6K and the 4E-BP protein”
• mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. (2002, background): “…of mRNA translation, ribosome synthesis, expression of metabolism-related genes, autophagy, and cytoskeletal reorganization (recently reviewed by Schmelzle and Hall, 2000, and by GinDo-Hyung Kim,1 Dos D. Sarbassov,1 Siraj M. Ali,1 Jessie E. King,1 Robert R. Latek,1 Hediye Erdjument-Bromage,2…”
• Current development of mTOR inhibitors as anticancer agents (2006, background): “The TOR family of proteins has pleiotropic functions, and participates in the regulation of the initiation of mRNA transcription and protein translation in response to intracellular concentrations of amino acids and other essential nutrients, in the organization of the actin cytoskeleton, membrane t”
• S6K1−/−/S6K2−/− Mice Exhibit Perinatal Lethality and Rapamycin-Sensitive 5′-Terminal Oligopyrimidine mRNA Translation and Reveal a Mitogen-Activated Protein Kinase-Dependent S6 Kinase Pathway (2004, background): “However, S6 phosphorylation in such animals was still sensitive to the bacterial macrolide rapamycin (51), which inhibits the mammalian target of rapamycin (mTOR) (1, 7, 16, 48 ), the upstream S6K1 kinase (4, 8, 18), suggesting the existence of a second S6K.”
• Nitrogen regulation in Saccharomyces cerevisiae. (2002, background): “The TOR kinases are central controllers of cell growth and their inactivation results in physiological changes leading to the cellular state characteristic of starvation and finally the total arrest of growth (Schmelzle and Hall, 2000).”
• Cell Wall Integrity Signaling in Saccharomyces cerevisiae (2005, background): “Despite their sequence similarity to lipid kinases (168), they have been shown to possess Ser/Thrspecific protein kinase activity (2, 290).”