Mammalian defensins in the antimicrobial immune response

By M. Selsted, A. Ouellette. Nature Immunology, 2005

1,246 citations recorded by the source corpus.

Subfields: Emergency Medical Services, Microbiology, Organic Chemistry

View Paper: https://www.semanticscholar.org/paper/cfea714ae33e3e5fde4f8c45089369c6cb9b2d78

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Emergency Medical Services

1. Robert E. W. Hancock
2. C. Nathan
3. M. Abreu
4. C. Bevins

In Microbiology

1. H. Jenssen
2. P. Hamill
3. Robert E. W. Hancock
4. C. Bevins
5. C. Nathan
6. DM Mosser
7. Daniel M Altmann
8. X. Zhang

In Organic Chemistry

1. Robert E. W. Hancock
2. C. Nathan
3. M. Abreu

Citations in the corpus

• Macrophage activation by endogenous danger signals (2008, background): “In addition to their antimicrobial and immunomodulatory effects, defensins also possess antiviral and toxinneutralizing properties [81].”
• Development, cytokine profile and function of human interleukin 17–producing helper T cells (2007, background): “These antimicrobial molecules are produced by epithelial and immune cells and protect the skin against bacterial, fungal and viral infectio”
• Neutrophils and immunity: challenges and opportunities (2006, background): “The defensins are small, cyclic polypeptides that trade off their relatively low molar potency against their high abundance and broad spectrum as antimicrobial agent”
• The immunology of sepsis (2008, background): “Surfactants containing antibacterial substances such as cathelicidins and defensins can destroy both Gram-positive and Gramnegative pathogens via pore-forming activity [13–15].”
• Peptide Antimicrobial Agents (2006, background): “A second prominent group of mammalian antimicrobial peptides is the defensins (70, 221), cyclic peptides which are categorized into three subfamilies on the basis of the disulfide pairings between their six conserved cysteine residues ( - and -defensins) or their macrocyclic nature ( -defensins).”
• Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis (2011, background): “In mammals, defensins are a major family of antimicrobial peptide”
• Defining Postpartum Uterine Disease and the Mechanisms of Infection and Immunity in the Female Reproductive Tract in Cattle (2009, neutral): “The AMPs are an ancient component of the immune system, and the defensins family is particularly important for mucosal immunity [69].”
• Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function (2010, background): “, Paneth cells are the main source of antimicrobial peptides, such as α-defensins (also known as cryptdins”