The stress system in the human brain in depression and neurodegeneration.

By Dick F. Swaab, A. Bao, P. Lucassen. Ageing Research Reviews, 2005

1,003 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Biological Psychiatry, Social Psychology

View Paper: https://www.semanticscholar.org/paper/d051aebaf7336f4c882b523a03b319f5019655cf

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Citations in the corpus

The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior (2007, background): “Glucocorticoids, stress and adult hippocampal neurogenesis Approximately 50% of depressed patients exhibit dysregulation of the hypothalamic–pituitary–adrenal (HPA) axis, which results in sustained elevations in cortisol levels (Gold and Chrousos, 2002; Swaab et al., 2005).”
Brain volume abnormalities in major depressive disorder: A meta‐analysis of magnetic resonance imaging studies (2009, background): “This is relevant, since MDD has been linked to disrupted HPA-axis activity and increased levels of cortisol [Bao et al., 2008; Swaab et al., 2005] which in turn has been postulated to effect hippocampal volume through the inhibition of neurogenesis in this brain structure [Czeh and Lucassen, 2007; H”
From inflammation to sickness and depression: when the immune system subjugates the brain (2008, background): “In biological psychiatry, CRH and vasopressin have a long history as candidate neuropeptides for accounting for symptoms of depressio”
Neurocircuitry of Mood Disorders (2010, background): “…to the plasma cortisol concentrations, and both deficits in negative feedback systems and excessive central stimulation of the secretion of CRF and/or other ACTH secretagogues are implicated in mood disorders (Gold and Chrousos, 2002; Drevets et al, 2004a; Swaab et al, 2005; Carroll et al, 2007).”
Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression (2008, background): “…(VBM) task, where a stimulus is shown briefly and then ‘‘masked’’ or covered in space using a noninformative stimulus, medicated BD subjects had deficits in the identification of masked stimuli, consistent with an impairment early in the information processing pathway (Fleming and Green 1995).”
11β-hydroxysteroid dehydrogenases: intracellular gate-keepers of tissue glucocorticoid action. (2013, background): “In this regard, exogenous glucocorticoids increase A and tau deposition in mouse models of Alzheimer’s disease (247), raising the intriguing possibility that the elevated cortisol levels seen in patients (688) may be more than CHAPMAN, HOLMES, AND SECKL”