A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness.

By Michael Maes, P. Gałecki, Y. Chang, Michael Berk. Progress in Neuro-psychopharmacology and Biological Psychiatry, 2011

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How researchers see this paper

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Oxidative Stress and the Central Nervous System (2017, positive): “of several key antioxidants in samples from depressed subjects (Maes et al., 2011).”
Understanding the somatic consequences of depression: biological mechanisms and the role of depression symptom profile (2013, background): “In addition, other recently indicated physiological mechanisms that could underlie the link between depression and somatic morbidity, such as the oxidative and nitrosative stress (O&NS) pathways [86], deserve further research.”
Is depression associated with increased oxidative stress? A systematic review and meta-analysis. (2015, positive): “A fast growing body of evidence suggests the involvement of a specific component of metabolic stress, oxidative stress, in the pathophysiology of depression (Maes et al., 2011).”