Oxidative Damage Is the Earliest Event in Alzheimer Disease

By A. Nunomura, George Perry, G. Aliev, K. Hirai, A. Takeda, E. Balraj, Paul K. Jones, H. Ghanbari, T. Wataya, S. Shimohama and 4 more. Journal of Neuropathology and Experimental Neurology, 2001

1,932 citations recorded by the source corpus.

Subfields: Nutrition and Dietetics, Physiology, Rheumatology

View Paper: https://www.semanticscholar.org/paper/cef7ca410832a144dc7c83e61eff4b8a35691afb

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Nutrition and Dietetics

1. Chunyan Guo
2. J. Kong
3. Xueping Chen

In Physiology

1. P. Reddy
2. M. Beal
3. Yan Zhao
4. Baolu Zhao
5. Xiongwei Zhu
6. M. O’Banion
7. Claudio Franceschi
8. O. Maier

Citations in the corpus

• Pharmacological and Clinical Aspects of Heme Oxygenase (2008, neutral): “Also increased oxidative damage (Nunomura et al., 2001; Praticò et al., 2002), iron accumulation (Schipper, 2004a). and HO-1 induction (Schipper et al., 1995) have been reported.”
• Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology. (2010, background): “Moreover, it has been shown that oxidative damage occurs before Aβ plaque formation [5] supporting a causative”
• Oxidative stress in neurodegenerative diseases (2012, background): “[52] Nunomura A, Perry G, Aliev G, et al.”
• Expression of Nrf2 in Neurodegenerative Diseases (2007, neutral): “Oxidative damage occurs early in disease (5, 7), suggesting that oxidative stress plays a role in disease progression.”
• Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease. (2008, background): “Oxidative stress and synaptic damage are known to implicate in Alzheimer’s disease (AD) pathogenesis [1–6], and may play a critical role in cognitive decline in elderly individuals and AD patients.”
• Interrelation of Oxidative Stress and Inflammation in Neurodegenerative Disease: Role of TNF (2015, background): “Importantly, oxidative damage of mitochondrial proteins andDNA occurs already in early stages of the disease suggesting a role of oxidative stress in disease progression [47, 49].”
• Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases (2006, neutral): “Oxidative damage occurs early in the AD brain, before the onset of significant plaque patholog”
• Inflammatory processes in Alzheimer's disease. (2007, background): “Although it is generally accepted that Aβ deposition is a potent glial activator, astrocyte and microglial activation could be an early event in the disease, occurring even in the absence of focal Aβ deposition (Nunomura et al., 2001).”
• Oxidative Stress and the Pathogenesis of Alzheimer's Disease (2013, background): “It was found that neuronal oxidative damage was more pronounced in AD subjects with lesser amounts of Abeta deposition or in AD subjects with a shorter disease duration [61, 62], and there was an inverse relationship between the levels of neuronal oxidative damage to nucleic acids and the amounts of”
• Mitochondria take center stage in aging and neurodegeneration (2005, background): “Oxidative damage occurs preceding -amyloid deposition.(16) A deficiency of -ketoglutarate dehydrogenase activity occurs in AD, as shown in both skin fibroblasts as well as in postmortem brain tissue.”
• The Continuum of Aging and Age-Related Diseases: Common Mechanisms but Different Rates (2018, background): “J Neuropathol Exp Neurol (2001) 60(8):759–67.”