Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans
By S. Saijo, N. Fujikado, T. Furuta, S. Chung, Hayato Kotaki, Keisuke Seki, K. Sudo, Shizuo Akira, Y. Adachi, N. Ohno and 4 more. Nature Immunology, 2007
636 citations recorded by the source corpus.
Subfields: Epidemiology, Infectious Diseases
View Paper: https://www.semanticscholar.org/paper/cdef181d429fedefcf5577691774daf9ebbc796d
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In Epidemiology
- Shizuo Akira
- R. Medzhitov
- Mihai G. Netea
- C. Reis e Sousa
- Gordon D. Brown
- N. Gow
- Y. Iwakura
- H. Ishigame
In Infectious Diseases
Citations in the corpus
- An integrated model of the recognition of Candida albicans by the innate immune system (2008, result): “However, these results are at odds with another study in dectin 1 −/− mice, which failed to discern increased susceptibility to candidiasi”
- Candida albicans morphogenesis and host defence: discriminating invasion from colonization (2011, positive): “The important role of dectin 1 and CARD9 in antifungal host defence has been confirmed by in vivo studie”
- Signalling through C-type lectin receptors: shaping immune responses (2009, background): “specifically, dectin 1 activates gene expression through the recognition of β-1,3-glucan PAMPs expressed by a broad range of fungal pathogens, including C. albicans, Aspergillus fumigatus and Pneumocystis carinii, which then leads to the activation of NF-κB 4, 17, 42, 43 (fIG.”
- Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17 (2007, background): “However, zymosan-induced production of IL-10 and IL-2 is almost normal in dectin-1-knockout DCs, indicating receptor redundanc”
- Recognition of microorganisms and activation of the immune response (2007, background): “This PRR has an important role in antifungal defenc”
- Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans. (2010, background): “However, Dectin-1 was not required for the defense against C. albicans in vivo, although it played some role for the defense against Pneumocystis carinii (Saijo et al., 2007).”