Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis.

By Jörn Karhausen, G. Furuta, John Tomaszewski, Richard J. Johnson, S. Colgan, V. Haase. Journal of Clinical Investigation, 2004

646 citations recorded by the source corpus.

Subfields: Cancer Research, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/cdcfb9352ffa554155616e03591e3476186689ec

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Citations in the corpus

Interdependence of hypoxic and innate immune responses (2009, result): “However, several other studies using different mouse colitis models indicated the opposite: a protective effect of HIF against colonic inflammation following genetic manipulatio”
Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system. (2007, positive): “However, intrarectal instillation of fluorescently labeled dextran, to test the integrity of the colonic epithelial barrier in 3.5 week-old mice (Karhausen et al., 2004) demonstrated significantly increased permeability in TRUC compared to RAG2-/and T-bet-/- mice (Figure 2B) with 2-fold higher…”
Inflammation, a Key Event in Cancer Development (2006, background): “In a murine model of experimental colitis, HIF-1 in hypoxic epithelium attenuates clinical manifestations of inflammatory disease as an anti-inflammatory factor (192).”
A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip (2019, neutral): “HIF-1 α is believed to control barrier integrity by regulating multiple barrier-protective genes, and its dysregulation may be involved in GI disorders 59,60 .”
Microbiota metabolite short chain fatty acids, GCPR, and inflammatory bowel diseases (2016, background): “Stabilization of hypoxia inducible factors (HIFs) has been revealed to protect against inflammation and maintain intestinal homeostasis [56, 57].”
Hypoxia-Inducible Factors in Physiology and Medicine (2012, background): “The severity of colitis induced by chemical (Karhausen et al., 2004) or bacterial (Hirota et al., 2010) toxins was increased in conditional knockout mice lacking HIF-1a expression in intestinal epithelial cells.”
Crosstalk between Microbiota-Derived Short-Chain Fatty Acids and Intestinal Epithelial HIF Augments Tissue Barrier Function (2015, positive): “This observation is supported by a growing literature that has established the role of HIF-1a in mucosal protection in vivo (Hindryckx et al., 2010; Karhausen et al., 2004; Keely et al., 2014, Robinson et al., 2008; Tambuwala et al., 2010).”
Mechanisms of inflammation-driven bacterial dysbiosis in the gut (2016, neutral): “coli expresses terminal oxidases that mediate aerobic respiration using oxygen as a terminal electron acceptor.(69) Expression of terminal oxidases is regulated at the transcriptional level by the O2 and NO3 sensing regulators FNR, ArcA/ B, NarX/L, and NarP/Q.”
Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease (2017, background): “coli express terminal oxidases that use oxygen as electron accep tor (188).”