Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease

By Joseph M Pickard, M. Zeng, R. Caruso, G. Núñez. Immunological Reviews, 2017

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How researchers see this paper

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Human gut microbiota in health and disease: Unveiling the relationship (2022, background): “Gut microbiota contributes to the stimulation and maturation of the immune system in response to pathogens, and it induces and sustains tolerance (Pickard et al., 2017).”
Oral microbiomes: more and more importance in oral cavity and whole body (2018, background): “Intestinal colonization by bacteria from the oral cavity has been suggested to be extensively involved in inflammatory diseases (Pickard et al., 2017; Caballero and Pamer, 2015).”
The microbiome and cancer (2018, background): “Reciprocally, the host preferentially retains or rejects certain organisms by using constraints such as antimicrobial peptides [23], inactivating IgA [24,25], and provision of metabolic substrates such as the proteoglycans of mucins [21,26].”
Cytokine Networks in the Pathophysiology of Inflammatory Bowel Disease. (2019, background): “and cytokine responsiveness by immune and intestinal cells and is reviewed in detail elsewhere (Pickard et al., 2017).”
Gut Bacteroides species in health and disease (2021, background): “Initially, during early infiltration in the extraintestinal organs, aerobic bacteria dominate and cause tissue damage.(84) Then, the redox potential of oxygenated tissues decreases, and anaerobes such as Bacteroides begin to thrive, leading to inflammation, diarrhea, and the formation of intra-abdom”