Interdependence of hypoxic and innate immune responses

By V. Nizet, Richard J. Johnson. Nature reviews. Immunology, 2009

744 citations recorded by the source corpus.

Hypoxia-inducible factor (HIF) is an important transcriptional regulator of cell metabolism and the adaptation to cellular stress caused by oxygen deficiency (hypoxia). Phagocytic cells have an essential role in innate immune defence against pathogens and this is a battle that takes place mainly in the hypoxic microenvironments of infected tissues. It has now become clear that HIF promotes the bactericidal activities of phagocytic cells and supports the innate immune functions of dendritic cells, mast cells and epithelial cells. In response to microbial pathogens, HIF expression is upregulated through pathways involving the key immune response regulator nuclear factor-κB, highlighting an interdependence of the innate immune and hypoxic responses to infection and tissue damage. In turn, HIF-driven innate immune responses have important consequences for both the pathogen and the host, such that the tissue microenvironment fundamentally influences susceptibility to infectious disease.

Subfields: Cancer Research, Immunology

View Paper: https://www.semanticscholar.org/paper/a7ec296ad533b08c736baf6f8ca664e0b0401def

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Citations in the corpus

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells (2011, background): “Although HIF1 is known to be induced by hypoxic conditions through a posttranslational-dependent mechanism, HIF1 can be up-regulated by NF-B signaling in activated innate immune cells under normoxia (Rius et al., 2008; Nizet and Johnson, 2009).”
Hypoxia and mitochondrial oxidative metabolism. (2010, background): “disorders, such as type 2 diabetes [1,2], Alzheimer's disease [3,4], cardiac ischemia/reperfusion injury [5,6], tissue inflammation [7], and”
Macrophage plasticity and polarization in tissue repair and remodelling (2013, background): “M1-activated macrophages are often associated with acute infection; these cells need to quickly trigger microbicidal activity as well as keep up with the hypoxic tissue microenvironment [55].”
Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases (2011, background): “In addition, acidity and low oxygen tensions undermine antitumour surveillance by turning immune cells into facilitators of invasion and angiogenesi”
Molecular Mechanisms That Influence the Macrophage M1–M2 Polarization Balance (2014, result): “This is in line with the finding that HIF-1α was induced by NF-κB (57) and plays an important role in modulating macrophage phagocytosis of bacteria under sepsis conditions (58).”