Mechanisms of inflammation-driven bacterial dysbiosis in the gut
By M. Zeng, N. Inohara, G. Núñez. Mucosal Immunology, 2016
788 citations recorded by the source corpus.
The gut microbiota has diverse and essential roles in host metabolism, development of the immune system and as resistance to pathogen colonization. Perturbations of the gut microbiota, termed gut dysbiosis, are commonly observed in diseases involving inflammation in the gut, including inflammatory bowel disease, infection, colorectal cancer and food allergies. Importantly, the inflamed microenvironment in the gut is particularly conducive to blooms of Enterobacteriaceae, which acquire fitness benefits while other families of symbiotic bacteria succumb to environmental changes inflicted by inflammation. Here we summarize studies that examined factors in the inflamed gut that contribute to blooms of Enterobacterieaceae, and highlight potential approaches to restrict Enterobacterial blooms in treating diseases that are otherwise complicated by overgrowth of virulent Enterobacterial species in the gut.
Subfields: Food Science, Infectious Diseases, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/c89c419947d60e8e7b9b4faa34efdc5031df4ff6
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Citations in the corpus
- Alteration of Gut Microbiota in Inflammatory Bowel Disease (IBD): Cause or Consequence? IBD Treatment Targeting the Gut Microbiome (2019, background): “This disruption in the gut mic obiota balance ulti ately results in an alteration of t gut micro flora-associated functions, including alteration of fermentation products such as carbohydr tes, vit mi s, and SCFAs [53], and biochemical proces alteratio s, such as immune equilibrium imbalance [54–56]”
- Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease (2017, background): “This suggests that in the steady state perhaps a small number of Gram-negative Enterobacterial species, which have been shown to possess unique growth advantages that enable them to bloom in an inflamed gut (129), may be uniquely equipped for successful penetration of the gut epithelial barrier, eva”