FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK
By M. Essers, S. Weijzen, A. M. D. de Vries-Smits, I. Saarloos, N. de Ruiter, J. Bos, Boudewijn M. T. Burgering. EMBO Journal, 2004
855 citations recorded by the source corpus.
Subfields: Aging, Molecular Biology, Plant Science
View Paper: https://www.semanticscholar.org/paper/cd9b9649e9fb2daf563ec3ad227a99b275b3bff4
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Aging
- A. Brunet
- Esther B. E. Becker
- Zengqiang Yuan
- J. Villén
- Rute Martins
- Yue Yang
- Peter R. Boag
- Steven P. Gygi
In Molecular Biology
- J. Villén
- Steven P. Gygi
- C. Weston
- A. Brunet
- Dervis A M Salih
- M. Birnbaum
- A. V. D. Heuvel
- David H. Gross
Citations in the corpus
- A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. (2006, positive): “Recent evidence suggests that the protein kinase JNK also signals via FOXO proteins to trigger cellular and organism-wide responses by opposing growth-factor regulation of FOXO proteins (Essers et al., 2004; Oh et al., 2005; Wang et al., 2005).”
- FoxO transcription factors in the maintenance of cellular homeostasis during aging. (2008, background): “The induction of apoptosis by dFOXO in the fly retina requires activation of the JNK pathway, further supporting the idea that JNK activates FoxO factors [10,77].”
- Increased muscle PGC-1α expression protects from sarcopenia and metabolic disease during aging (2009, background): “The aged wild-type animals also showed greatly increased inf lammatory markers TNF and IL-6 in skeletal muscle compared to their age-matched MCK-PGC-1 littermates (Fig.”
- The role of FoxO in the regulation of metabolism (2008, background): “There is also a corresponding reduction in Pdx-1 expression and DNAbinding activity in response to JNK activation (Kaneto et al., 2002; Kawamori et al., 2003, 2006).”
- FOXO transcription factors at the interface between longevity and tumor suppression (2005, background): “In mammalian cells, the phosphorylation of FOXO4 by JNK also results in the translocation of FOXO from the cytoplasm to the nucleus (Essers et al., 2004).”
- The JNK signal transduction pathway. (2007, background): “JNK-stimulated activation of FOXO transcription factors [63 ,64] may also contribute to the increased Bim expression [65].”