The JNK signal transduction pathway.

By C. Weston, R. Davis. Current Opinion in Genetics and Development, 2007

1,627 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/c3fd6ffba6be4f01eeb3f921f460b542f1cbdab6

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In Molecular Biology

1. Zena Werb
2. M. Egeblad
3. Andrew J. Ewald
4. Beth Levine
5. R. Roskoski
6. D. Trachootham
7. Peng Huang
8. M. Junttila

In Oncology

1. Zena Werb
2. M. Egeblad
3. Andrew J. Ewald
4. M. Krummel
5. B. Welm
6. Morgan L. Truitt
7. G. Peeters
8. H. Askautrud

In Pathology and Forensic Medicine

1. R. Roskoski
2. Simone Fulda

Citations in the corpus

• Phosphatase‐mediated crosstalk between MAPK signaling pathways in the regulation of cell survival (2008, background): “JNK also has other nontranscriptional substrates, for example the antiapoptotic proteins, Bcl-2 and Bcl-xL (2, 5, 34).”
• Cellular Stress Responses: Cell Survival and Cell Death (2010, background): “Conversely, the failure to activate or maintain a protective response, for example, if the stressful agent is too strong, results in activation of stress signaling cascades that eventually fuel into cell death pathways [81, 82].”
• Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy (2008, background): “In species ranging from yeast to vertebrates, JNK signaling has been implicated in the response to many forms of environmental stress, including radiation, osmotic stress, redox stress and nutrient imbalance (Weston and Davis, 2007).”
• ERK1/2 MAP kinases: structure, function, and regulation. (2012, background): “The JNK pathway consists f JNK1–3, a MAP2K such as MAP2K4 (also known as SEK1) or AP2K7, and a MAP3K such as ASK1 or TAK1 (both of which also unction in the p38 pathway), MEKK1, or mixed-lineage kinase MLK) [12].”
• Tumor resistance to apoptosis (2009, background): “Various stress-inducible molecules, for example JNK, MAPK/ERK, NFjB or ceramide have been implicated in propagating the apoptotic signal.(14,15) Further, oncogenic events such as deregulated expression of the myc oncogene can trigger apoptosis besides stimulating tumor growth.”
• Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update. (2012, background): “JNKs, while activated by mitogens, are also vigorously activated by a variety of environmental stresses (heat shock, ionizing radiation, oxidants), genotoxins (topoisomerase inhibitors and alkylating agents), ischemic reperfusion injury, mechanical shear stress, vasoactive peptides, proinflammatory ”
• Redox Regulation of Cell Survival (2008, positive): “The inhibition of antiapoptotic proteins and the activation of BH3-only proteins may promote translocation and activation of Bax/Bak, leading to mitochondria-mediated apoptosis (331).”
• JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. (2008, background): “One speculation is that, in metazoans, there is a need that does not exist in unicellular organisms for coordinate regulation of starvation responses and autophagy with other pathways such as cellular proliferation, differentiation, development, inflammation, and apoptosis that are also regulated by”